Schmidt E, Schmidt F W
Abteilung Gastroenterologie und Hepatologie, Medizinische Hochschule, Hannover, FRG.
Clin Biochem. 1990 Oct;23(5):383-94. doi: 10.1016/0009-9120(90)90102-z.
This paper reviews recent developments of analytical methods for the determination of alpha-amylase, of its isoenzymes, and of lipase. The evaluation of severity and etiology of acute pancreatitis by enzyme assays, e.g., pancreatic elastase 1, phospholipase A2, and routine enzymes are discussed. The limited significance of enzyme determinations as compared to imaging and endoscopic procedures for the diagnosis of chronic pancreatitis is demonstrated. Indirect "tubeless" tests for the evaluation of pancreatic exocrine insufficiency with respect to the secretion of chymotrypsin (chymotrypsin in stool and NBT-PABA test) and cholesterol esterase (pancreolauryl test) are reviewed. Finally, the superiority of morphologic investigations over biochemical tests for the timely detection of pancreatic carcinoma is shown.
本文综述了用于测定α-淀粉酶、其同工酶和脂肪酶的分析方法的最新进展。讨论了通过酶测定法，如胰弹性蛋白酶1、磷脂酶A2和常规酶，来评估急性胰腺炎的严重程度和病因。证明了与用于诊断慢性胰腺炎的影像学和内镜检查程序相比，酶测定的意义有限。综述了用于评估胰腺外分泌功能不全的关于胰凝乳蛋白酶分泌（粪便中的胰凝乳蛋白酶和NBT-PABA试验）和胆固醇酯酶（月桂醇试验）的间接“无管”试验。最后，显示了形态学检查在及时检测胰腺癌方面优于生化试验。
