First Department of Internal Medicine, Gifu University Hospital, Gifu, Japan.
Dig Endosc. 2012 May;24 Suppl 1:28-33. doi: 10.1111/j.1443-1661.2012.01273.x.
Currently, endoscopic intervention is widely attempted as the first-line treatment of benign biliary strictures because of its convenience and low morbidity. Plastic tube stents (PS) are usually used for such treatment; however, covered self-expandable metallic stents (C-SEMS) are becoming more commonly used at some institutions. The temporary placement of C-SEMS may lead to better outcomes because of their larger diameter and, therefore, better dilation of the stricture, especially in refractory cases. The aim of the present study was to evaluate the efficacy of the temporary placement of C-SEMS in the management of benign biliary strictures.
We retrospectively reviewed our endoscopic retrograde cholangiopancreatography (ERCP) database (May 1996 to December 2010), and extracted the data of patients who underwent endoscopic treatment for benign biliary strictures. Then, the follow-up data from patient charts were reviewed to determine the long-term outcomes of those procedures.
All patients (n = 56) initially had a PS placed, with or without balloon dilation. However, C-SEMS placement was later attempted in 12 patients because the stricture was refractory to placement of the PS. During their follow-up periods, two patients died of unrelated diseases after 15 and 17 months, and another two still had the C-SEMS in place after 9 and 50 months. In the remaining eight patients, the C-SEMS was removed after a median placement period of 6 months (range, 2-15). Seven patients in this group have not experienced a recurrence at a median follow-up time of 48 months. However, in one patient, stenosis did recur 8 months after the C-SEMS was removed.
Temporary placement of C-SEMS can be a treatment option for benign biliary strictures, especially in refractory cases.
目前,由于其便利性和低发病率,内镜介入已广泛尝试作为良性胆道狭窄的一线治疗方法。通常使用塑料支架(PS)进行此类治疗;然而,在一些机构,覆膜自膨式金属支架(C-SEMS)的使用越来越普遍。由于其较大的直径,C-SEMS 的临时放置可能会导致更好的结果,因此可以更好地扩张狭窄,特别是在难治性病例中。本研究旨在评估 C-SEMS 临时放置在良性胆道狭窄治疗中的疗效。
我们回顾性地审查了我们的内镜逆行胰胆管造影(ERCP)数据库(1996 年 5 月至 2010 年 12 月),并提取了接受内镜治疗良性胆道狭窄的患者数据。然后,从患者病历中回顾随访数据,以确定这些手术的长期结果。
所有患者(n=56)最初都放置了 PS,无论是否进行球囊扩张。然而,由于 PS 放置后狭窄仍然存在,后来对 12 名患者尝试了 C-SEMS 放置。在随访期间,两名患者在 15 个月和 17 个月后因与疾病无关的原因死亡,另外两名患者在 9 个月和 50 个月后仍保留 C-SEMS。在其余 8 名患者中,C-SEMS 在中位放置期 6 个月(范围 2-15 个月)后被取出。这组患者中有 7 人在中位随访时间 48 个月内未复发。然而,在一名患者中,C-SEMS 取出后 8 个月狭窄再次复发。
C-SEMS 的临时放置可以作为良性胆道狭窄的治疗选择,尤其是在难治性病例中。