急性间歇性卟啉病中血乳酸和丙酮酸水平升高——是血红素缺乏的反映吗？
Elevation of blood lactate and pyruvate levels in acute intermittent porphyria--a reflection of haem deficiency?
作者信息
Herrick A L, Fisher B M, Moore M R, Cathcart S, McColl K E, Goldberg A
机构信息
University Department of Medicine & Therapeutics and Pathological Biochemistry, Western Infirmary, Glasgow Scotland.
出版信息
Clin Chim Acta. 1990 Oct 15;190(3):157-62. doi: 10.1016/0009-8981(90)90169-s.
Blood lactate concentrations after glucose loading were significantly higher in 6 patients with acute intermittent porphyria in clinical remission than in 6 control subjects and the percentage rise in glucose pyruvate and lactate concentrations were greater in the porphyric subjects than in the control group. It is postulated that the raised lactate levels in the porphyric patient group may reflect haem deficiency affecting the cytochromes of the terminal respiratory chain.
6例处于临床缓解期的急性间歇性卟啉病患者在葡萄糖负荷后血乳酸浓度显著高于6例对照受试者，且卟啉病患者组中葡萄糖、丙酮酸和乳酸浓度的升高百分比高于对照组。据推测，卟啉病患者组中升高的乳酸水平可能反映了影响终末呼吸链细胞色素的血红素缺乏。
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