饥饿-再喂养过渡期及冷暴露期间大鼠棕色脂肪组织和肝脏中脂肪生成酶活性的比较研究。

Comparative studies on lipogenic enzyme activities in brown adipose tissue and liver of the rat during starvation-refeeding transition and cold exposure.

Zelewski M, Swierczyński J

Department of Biochemistry, Academic Medical School, Gdańsk, Poland.

Comp Biochem Physiol B. 1990;97(1):59-63. doi: 10.1016/0305-0491(90)90178-v.

Abstract

The effect of starvation-refeeding transition and cold exposure on the activity of lipogenic enzymes in brown adipose tissue (BAT) and liver from rats was compared. 2. Starvation caused a decrease of lipogenic enzyme activities in BAT and liver. 3. Refeeding of the animals with a high carbohydrate diet caused an increase of lipogenic enzymes in these tissues. 4. Cold exposure (4 degrees C for 30 days) led to the increase of BAT enzyme activities to the values observed in rats fed a high carbohydrate diet. 5. Under the same conditions the activity of hepatic lipogenic enzymes also increased but never reached the values observed in the liver of rats fed with a high carbohydrate diet. 6. Therefore BAT and liver lipogenic enzymes showed, in general, a similar pattern of variation under identical nutritional conditions, but substantial differences between these two organs occurred as far as the response to cold exposure was concerned. 7. The experiments also revealed that in the control animals BAT displayed a higher lipogenic potential than the liver.

摘要

比较了饥饿-再喂养转变和冷暴露对大鼠棕色脂肪组织（BAT）和肝脏中脂肪生成酶活性的影响。2. 饥饿导致BAT和肝脏中脂肪生成酶活性降低。3. 用高碳水化合物饮食再喂养动物导致这些组织中脂肪生成酶增加。4. 冷暴露（4℃，30天）导致BAT酶活性增加至喂食高碳水化合物饮食的大鼠中观察到的值。5. 在相同条件下，肝脏脂肪生成酶的活性也增加，但从未达到喂食高碳水化合物饮食的大鼠肝脏中观察到的值。6. 因此，在相同营养条件下，BAT和肝脏脂肪生成酶总体上显示出相似的变化模式，但就对冷暴露的反应而言，这两个器官之间存在显著差异。7. 实验还表明，在对照动物中，BAT显示出比肝脏更高的脂肪生成潜力。