Eastman Dental Hospital.
Br Dent J. 2012 Apr 27;212(8):377-9. doi: 10.1038/sj.bdj.2012.314.
Amelogenesis imperfecta (AI) is an inherited disorder that is associated with mutations in five genes (AMEL; ENAM; MMP20; KLK4 and FAM83H) with a wide range of clinical presentations (phenotypes). It affects the structure and appearance of enamel of all teeth, both in the primary and secondary dentition. In this review paper, we look at the epidemiology, classification, aetiology, clinical description and diagnosis of AI. In the following three papers of this series, we aim to describe the role of paediatric dentists, orthodontists and restorative dentists in the clinical management of patients with AI.
遗传性牙釉质发育不全（AI）是一种与五个基因（AMEL；ENAM；MMP20；KLK4 和 FAM83H）的突变相关的疾病，其临床表现（表型）范围广泛。它影响所有牙齿的釉质结构和外观，包括乳牙和恒牙。在这篇综述论文中，我们探讨了 AI 的流行病学、分类、病因、临床描述和诊断。在本系列的后三篇论文中，我们旨在描述儿童牙医、正畸医生和修复牙医在 AI 患者临床管理中的作用。
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