Senatore Massimo, Mollica Agata, Papalia Teresa, Bonofiglio Renzo
U.O.C. di Nefrologia, Dialisi e Trapianto, Ospedale Annunziata, Cosenza, Italy.
G Ital Nefrol. 2012 Mar-Apr;29(2):174-82.
Since phosphorus plays a critical role in diverse biological processes, regulation of the phosphorus balance and homeostasis are critical to the well-being of the organism. Recent findings point to the presence of a phosphate-sensing mechanism in the various organs and the presence of novel intestinal effectors that alter the renal phosphate excretion after the ingestion of a phosphate-containing meal. Recent studies have provided strong evidence that the sodium-phosphate cotransporter NaPi-IIb is responsible for sodium-dependent phosphate absorption by the small intestine, and this protein might link changes in dietary phosphate to altered renal phosphate excretion in order to maintain the phosphate balance. It has been established that different regions of the small intestine respond differently to acute or chronic changes in dietary phosphate load and that phosphatonins inhibit both renal and intestinal phosphate transport.
由于磷在多种生物过程中起着关键作用，磷平衡和内稳态的调节对于生物体的健康至关重要。最近的研究结果表明，在各个器官中存在一种磷酸盐感知机制，并且存在新型肠道效应器，它们在摄入含磷食物后会改变肾脏的磷酸盐排泄。最近的研究提供了强有力的证据，表明钠-磷酸盐共转运蛋白NaPi-IIb负责小肠对钠依赖性磷酸盐的吸收，并且这种蛋白质可能将饮食中磷酸盐的变化与肾脏磷酸盐排泄的改变联系起来，以维持磷酸盐平衡。已经确定，小肠的不同区域对饮食中磷酸盐负荷的急性或慢性变化有不同的反应，并且磷调节素会抑制肾脏和肠道的磷酸盐转运。
