从人三叉神经节、颈上神经节和迷走神经节外植体中分离出的1型单纯疱疹病毒自发分离株的多肽和DNA限制性内切酶图谱。

The polypeptide and the DNA restriction enzyme profiles of spontaneous isolates of herpes simplex virus type 1 from explants of human trigeminal, superior cervical and vagus ganglia.

作者信息

Warren K G, Koprowski H, Lonsdale D M, Brown S M, Subak-Sharpe J H

出版信息

J Gen Virol. 1979 Apr;43(1):151-71. doi: 10.1099/0022-1317-43-1-151.

Abstract

Analysis of the infected cell polypeptides and the DNA restriction profiles of 31 HSV-1 isolates from the trigeminal, superior cervical and vagus ganglia from 17 individuals (12 U.S.A., 2 Japanese, 3 Norwegian) could be classified as 15 different virus strains. With the exception of the three Norwegian isolates which gave identical profiles, virus isolates from the ganglia of different individuals could all be distinguished from one another. In contrast virus isolates from the trigeminal, superior cervical and vagus ganglia of the same individual, or virus isolates from the left and right ganglia of the same individual or multiple isolates from different explants of a single ganglion were indistinguishable. In conclusion, a single virus strain infects each individual initially and virus descended from this event subsequently infects and becomes latent in different cells of the same ganglion as well as in different ganglia.

摘要

对来自17名个体（12名美国人、2名日本人、3名挪威人）三叉神经节、颈上神经节和迷走神经节的31株单纯疱疹病毒1型（HSV-1）分离株的感染细胞多肽和DNA限制性图谱进行分析，结果显示这些分离株可分为15种不同的病毒株。除了3株挪威分离株具有相同的图谱外，来自不同个体神经节的病毒分离株彼此均可区分。相比之下，来自同一个体三叉神经节、颈上神经节和迷走神经节的病毒分离株，或来自同一个体左右神经节的病毒分离株，或来自单个神经节不同外植体的多个分离株均无法区分。总之，最初每种病毒株感染一个个体，随后由这一事件衍生出的病毒会感染同一神经节的不同细胞以及不同神经节，并在其中潜伏。