DNA转座元件在神经系统发育过程中的表达：关于其可能功能的讨论。

Expression of DNA transposable elements during nervous system development: A discussion about its possible functions.

作者信息

Faunes Fernando, Lee-Liu Dasfne, Larrain Juan

出版信息

Mob Genet Elements. 2011 Nov 1;1(4):296-300. doi: 10.4161/mge.18550.

DOI:10.4161/mge.18550

PMID:22545242

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3337140/

Abstract

Transposable elements (retrotransposons and DNA transposons) comprise a large proportion of animal genomes, for example 20% in D. melanogaster, 36% in X. tropicalis and 45% in humans. After invading a new genome, the transposable element increases its copy number and subsequently accumulates mutations. These may eventually result in inactive copies. Until recent days transposons have been considered "junk" DNA and no clear function have been assigned for this important amount of information on genomes.

摘要

转座元件（逆转座子和DNA转座子）在动物基因组中占很大比例，例如在黑腹果蝇中占20%，在热带爪蟾中占36%，在人类中占45%。侵入新基因组后，转座元件会增加其拷贝数，随后积累突变。这些突变最终可能导致产生无活性的拷贝。直到最近，转座子一直被视为“垃圾”DNA，而对于基因组中如此大量的重要信息，尚未赋予其明确的功能。