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转座元件在吸虫整个生命周期中的表达

Expression of Transposable Elements throughout the Trematode Life Cycle.

作者信息

Skalon Elizaveta K, Panyushev Nick V, Podgornaya Olga I, Smolyaninova Anastasia R, Solovyeva Anna I

机构信息

Zoological Institute, Russian Academy of Sciences, 199034 St. Petersburg, Russia.

Bioinformatics Institute, 197342 St. Petersburg, Russia.

出版信息

Noncoding RNA. 2024 Jul 3;10(4):39. doi: 10.3390/ncrna10040039.

DOI:10.3390/ncrna10040039
PMID:39051373
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11270206/
Abstract

BACKGROUND

Transposable elements (TEs) are major components of eukaryotic genomes. The extensive body of evidence suggests that although they were once considered "genomic parasites", transposons and their transcripts perform specific functions, such as regulation of early embryo development. Understanding the role of TEs in such parasites as trematodes is becoming critically important. , a parasite affecting humans and livestock, undergoes a complex life cycle in diverse environments and hosts, and knowledge about its life cycle regulation is scarce so far.

METHODS

We summarized the data regarding the repetitive elements in and conducted bulk RNA-seq analysis across its life cycle stages. TE expression profiles were analyzed, focusing on differential expression and potential homology with previously described long non-coding RNAs (lncRNAs).

RESULTS

Differential expression analysis revealed stage-specific TE transcription patterns, notably peaking during egg and metacercariae stages. Some TEs showed homology with known lncRNAs and contained putative transcription factor binding sites. Interestingly, TE transcription levels were highest in eggs and metacercariae compared to adults, suggesting regulatory roles in trematode life cycle transitions.

CONCLUSIONS

These findings suggest that TEs may play roles in regulating trematode life cycle transitions. Moreover, TE homology with lncRNAs underscores their significance in gene regulation.

摘要

背景

转座元件（TEs）是真核生物基因组的主要组成部分。大量证据表明，尽管转座子及其转录本曾被视为“基因组寄生虫”，但它们执行特定功能，如调节早期胚胎发育。了解转座元件在吸虫等寄生虫中的作用变得至关重要。吸虫是一种感染人类和牲畜的寄生虫，在不同环境和宿主中经历复杂的生命周期，而目前关于其生命周期调节的知识匮乏。

方法

我们总结了有关吸虫中重复元件的数据，并对其生命周期各阶段进行了批量RNA测序分析。分析了转座元件的表达谱，重点关注差异表达以及与先前描述的长链非编码RNA（lncRNAs）的潜在同源性。

结果

差异表达分析揭示了阶段特异性的转座元件转录模式，尤其是在虫卵和尾蚴阶段达到峰值。一些转座元件与已知的长链非编码RNA具有同源性，并含有假定的转录因子结合位点。有趣的是，与成虫相比，虫卵和尾蚴中转座元件的转录水平最高，表明其在吸虫生命周期转变中发挥调节作用。

结论

这些发现表明转座元件可能在调节吸虫生命周期转变中发挥作用。此外，转座元件与长链非编码RNA的同源性凸显了它们在基因调控中的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d84d/11270206/806dc69a9b99/ncrna-10-00039-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d84d/11270206/14249a0219e8/ncrna-10-00039-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d84d/11270206/4ffd9f78f815/ncrna-10-00039-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d84d/11270206/be6a2853a3e5/ncrna-10-00039-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d84d/11270206/55751c2ab89c/ncrna-10-00039-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d84d/11270206/09bae4c79eed/ncrna-10-00039-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d84d/11270206/e45b5e39c570/ncrna-10-00039-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d84d/11270206/e70154b475f3/ncrna-10-00039-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d84d/11270206/4e3c0b7270ee/ncrna-10-00039-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d84d/11270206/806dc69a9b99/ncrna-10-00039-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d84d/11270206/14249a0219e8/ncrna-10-00039-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d84d/11270206/4ffd9f78f815/ncrna-10-00039-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d84d/11270206/be6a2853a3e5/ncrna-10-00039-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d84d/11270206/55751c2ab89c/ncrna-10-00039-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d84d/11270206/09bae4c79eed/ncrna-10-00039-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d84d/11270206/e45b5e39c570/ncrna-10-00039-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d84d/11270206/e70154b475f3/ncrna-10-00039-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d84d/11270206/4e3c0b7270ee/ncrna-10-00039-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d84d/11270206/806dc69a9b99/ncrna-10-00039-g009.jpg

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