The University of Tennessee Health Sciences Center, Memphis, TN, USA.
Issues Ment Health Nurs. 2012 May;33(5):342-3. doi: 10.3109/01612840.2012.669025.
Lurasidone is a new atypical antipsychotic that has demonstrated positive effects on psychosis, mood, and cognition. This improved efficacy and safety profile for the treatment of schizophrenia. Its overall tolerability profile seems to be comparable to the other atypical antipsychotics. Perhaps its more potent blockade on the 5HT7 receptor will give it more of an advantage in treating the negative symptoms as well as improve cognitive and depressive symptoms associated with schizophrenia. Additionally, it does not appear to have any significant adverse impact on the metabolic profile, such as weight, glucose, or lipid metabolism. Lurasidone is also associated with good cardiovascular tolerability without widening of the QT interval. The use of this medication may be of particular interest in patients presenting with endocrine or cardiovascular abnormalities. The average price for a 30-day supply of lurasidone is $475.98.
鲁拉西酮是一种新型的非典型抗精神病药物，已被证明对精神病、情绪和认知具有积极影响。这改善了治疗精神分裂症的疗效和安全性。其总体耐受性似乎与其他非典型抗精神病药物相当。也许它对 5-HT7 受体的更强阻断作用将使它在治疗阴性症状方面更具优势，并改善与精神分裂症相关的认知和抑郁症状。此外，它似乎对代谢谱没有任何重大不利影响，如体重、葡萄糖或脂质代谢。鲁拉西酮也与良好的心血管耐受性相关，不会导致 QT 间期延长。对于存在内分泌或心血管异常的患者，这种药物的使用可能特别有意义。鲁拉西酮 30 天用量的平均价格为 475.98 美元。
