Hematology/Oncology Department, L'Archet Hospital, Nice, France.
Curr Hematol Malig Rep. 2012 Sep;7(3):228-34. doi: 10.1007/s11899-012-0125-2.
Hodgkin lymphoma (HL) is one of the most common types of non-AIDS-defining tumors in the HIV-infected. Its incidence however seems to have increased under highly active anti-retroviral therapy (HAART). HIV-HL is a different entity from HL in HIV-negative subjects with a poorer prognosis that is associated with tumor-subtype, EBV-infection, and "B" symptoms. Despite the aggressive nature of the disease, clinical outcome has improved with combination therapies including appropriately timed antiretroviral strategies and the quality of supportive care-notably the use of hematopoietic growth factors. More intensive chemotherapy regimens with or without autologous stem cell transplantation appear to improve survival. Functional imaging such as positron emission tomography and computed tomography (FDG-PET) may help guide treatment strategy and minimize long-term toxicity.
霍奇金淋巴瘤（HL）是 HIV 感染者中最常见的非艾滋病定义性肿瘤之一。然而，在高效抗逆转录病毒治疗（HAART）下，其发病率似乎有所增加。HIV-HL 与 HIV 阴性患者中的 HL 不同，其预后较差，与肿瘤亚型、EBV 感染和“B”症状有关。尽管疾病具有侵袭性，但随着包括适时抗逆转录病毒策略和支持性护理质量（尤其是造血生长因子的使用）在内的联合治疗，临床结果已得到改善。更强化的化疗方案联合或不联合自体干细胞移植似乎可以提高生存率。功能成像，如正电子发射断层扫描和计算机断层扫描（FDG-PET），可能有助于指导治疗策略并最大程度地减少长期毒性。
