Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 1830 East Monument Street, 5th Floor, Baltimore, MD 21205, USA.
Cardiol Clin. 2012 May;30(2):243-56. doi: 10.1016/j.ccl.2012.03.005.
Right ventricular (RV) dysfunction arises in chronic lung disease when chronic hypoxemia and disruption of pulmonary vascular beds increase ventricular afterload. RV dysfunction is defined by hypertrophy with preserved myocardial contractility and cardiac output. RV hypertrophy seems to be a common complication of chronic and advanced lung disease. RV failure is rare, except during acute exacerbations of chronic lung disease or when multiple comorbidities are present. Treatment is targeted at correcting hypoxia and improving pulmonary gas exchange and mechanics. There are no data supporting the use of pulmonary hypertension-specific therapies for patients with RV dysfunction secondary to chronic lung disease.
右心室（RV）功能障碍发生在慢性肺部疾病中，当慢性低氧血症和肺血管床破坏增加心室后负荷时。RV 功能障碍的定义是心肌收缩力和心输出量正常的心肌肥厚。RV 肥厚似乎是慢性和晚期肺部疾病的常见并发症。RV 衰竭很少见，除非在慢性肺部疾病的急性加重期间或存在多种合并症时。治疗的目的是纠正缺氧，改善肺气体交换和力学。没有数据支持使用肺动脉高压特异性疗法治疗由慢性肺部疾病引起的 RV 功能障碍患者。
