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Northern blot analysis of HLA-G expression by BeWo human choriocarcinoma cells.

作者信息

Risk J M, Johnson P M

机构信息

Department of Immunology, University of Liverpool, U.K.

出版信息

J Reprod Immunol. 1990 Sep;18(2):199-203. doi: 10.1016/0165-0378(90)90017-z.

DOI:10.1016/0165-0378(90)90017-z
PMID:2254882
Abstract

The BeWo human choriocarcinoma cell line expresses an unusual 41 kDa beta 2-microglobulin-associated class I MHC antigen. HLA-E, -F and -G are known to encode antigens of lower Mr than HLA-A, -B or -C proteins. Using locus-specific probes, we now show that RNA isolated from BeWo cells contains markedly more HLA-G transcripts than peripheral blood lymphocytes (PBL), whilst the converse was noted for HLA-B. These results support recent cloning and sequencing data showing the presence of HLA-G transcripts in BeWo cells.

摘要

相似文献

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Northern blot analysis of HLA-G expression by BeWo human choriocarcinoma cells.
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2
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Human trophoblast and the choriocarcinoma cell line BeWo express a truncated HLA Class I molecule.人滋养层细胞和绒毛膜癌细胞系BeWo表达一种截短的HLA I类分子。
J Immunol. 1990 Jan 15;144(2):731-5.

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Expression of the CD46 antigen, and absence of class I MHC antigen, on the human oocyte and preimplantation blastocyst.人类卵母细胞和植入前胚泡上CD46抗原的表达及I类主要组织相容性复合体抗原的缺失。
Immunology. 1992 Jan;75(1):202-5.