Herlin Gunnar, Lundell Lars, Ost Ake, Aspelin Peter, Svensson Leif, Axelsson Rimma
Division of Medical Imaging and Technology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, 141 86 Stockholm, Sweden.
Radiol Res Pract. 2012;2012:415616. doi: 10.1155/2012/415616. Epub 2012 Feb 28.
Background. Somatostatin receptors (SSTRs) are over-expressed in several tumors making it possible for imaging with labelled SSTR. A previous study showed feasibility to image oesophageal cancer with SSTR analogue (99m)Tc-depreotide. Purpose. (1) To investigate expression of the SSTRs in different types of esophageal carcinoma and (2) to correlate such an expression with (99m)Tc-depreotide uptake in these lesions. Material and Methods. Total 28 patients (17 with esophageal cancer and 11 with Barrett's esophagus) were examined with (99m)Tc-depreotide scintigraphy. The SSTR2A, SSTR2B, SSTR3, and SSTR5 were analyzed immunohistochemically in the lesion samples. Results. Among the patients with adenocarcinoma 10/11 expressed different amounts of SSTRs, while SSTRs were absent in 5/6 patients with Squamous cell carcinoma (Sqcc). There was no correlation neither between the (99m)Tc-depreotide uptake and the amount of SSTRs nor between the amount of SSTRs and differentiation grade of the tumor. Conclusions. (1) SSTRs are expressed in esophageal carcinoma and more abundantly so in adenocancer specimens; (2) in vivo (99m)Tc-depreotide uptake does not obviously correlate with the immunohistochemically detection of SSTRs of different subtypes in esophageal carcinoma.
背景。生长抑素受体（SSTRs）在多种肿瘤中过度表达，这使得用标记的SSTR进行成像成为可能。先前的一项研究表明，用SSTR类似物（99m）Tc-地普奥肽对食管癌进行成像具有可行性。目的。（1）研究不同类型食管癌中SSTRs的表达情况；（2）将这种表达与这些病变中（99m）Tc-地普奥肽的摄取情况相关联。材料与方法。共28例患者（17例食管癌患者和11例巴雷特食管患者）接受了（99m）Tc-地普奥肽闪烁扫描检查。对病变样本进行免疫组织化学分析，检测SSTR2A、SSTR2B、SSTR3和SSTR5。结果。腺癌患者中，10/11表达了不同量的SSTRs，而鳞状细胞癌（Sqcc）患者中有5/6未表达SSTRs。（99m）Tc-地普奥肽摄取量与SSTRs量之间以及SSTRs量与肿瘤分化程度之间均无相关性。结论。（1）SSTRs在食管癌中表达，在腺癌标本中表达更丰富；（2）体内（99m）Tc-地普奥肽摄取与食管癌不同亚型SSTRs的免疫组织化学检测结果无明显相关性。
