Mount Sinai School of Medicine, 420 West 23rd Sreet, New York, NY, USA.
Expert Rev Vaccines. 2012 Apr;11(4):395-406. doi: 10.1586/erv.12.20.
Human papillomavirus infection causes cervical cancer, a significant portion of anal, genital and oropharyngeal cancers, genital warts and recurrent respiratory papillomatosis. In June 2006, a quadrivalent human papillomavirus-6/11/16/18 vaccine (GARDASIL/SILGARD®; Merck, NJ, USA) was licensed in the USA; subsequent approval has been granted in the EU (September 2006). It has since been approved in 121 countries with over 74 million doses distributed globally as of March 2011.
人乳头瘤病毒感染可引起宫颈癌，还可导致相当一部分肛门癌、生殖器癌和口咽癌、生殖器疣和复发性呼吸道乳头瘤病。2006 年 6 月，一种四价人乳头瘤病毒（HPV6/11/16/18）疫苗（加德西/希瑞适；默克公司，新泽西州，美国）在美国获得许可；随后在欧盟获得批准（2006 年 9 月）。自那时以来，该疫苗已在 121 个国家获得批准，截至 2011 年 3 月，已在全球分发了超过 7400 万剂。
