Institute for Animal Health, Pirbright Laboratory, Surrey GU24 0NF, UK.
Expert Rev Vaccines. 2012 Apr;11(4):481-93. doi: 10.1586/erv.11.198.
DNA vaccines are, in principle, the simplest yet most versatile methods of inducing protective humoral and cellular immune responses. Research involving this type of vaccine against veterinary diseases began in the early 1990s and has since seen the evaluation of more than 30 important viral pathogens, including the economically important foot-and-mouth disease. With the demonstration that DNA vaccines protect against foot-and-mouth disease in sheep and pigs, and the advantages these DNA vaccines have over the conventional formulations, this approach may provide a better solution to the control of this disease. In this review, we provide a comprehensive overview of DNA vaccination strategies for foot-and-mouth disease reported in the literature, in which we highlight the studies that have reported protection in the key target species.
DNA 疫苗在理论上是最简便、最具通用性的诱导保护性体液和细胞免疫应答的方法。从 20 世纪 90 年代初开始，针对兽医疾病的此类疫苗的研究不断发展，此后已有 30 多种重要的病毒病原体得到了评估，包括具有重要经济意义的口蹄疫。DNA 疫苗在绵羊和猪中对口蹄疫的保护作用已得到证实，并且与传统疫苗相比具有优势，因此这种方法可能为控制这种疾病提供更好的解决方案。在这篇综述中，我们全面概述了文献中报道的口蹄疫 DNA 疫苗接种策略，重点介绍了报告在关键目标物种中具有保护作用的研究。
