耐多药（MDR）肺炎克雷伯菌临床分离株：高异质性区（HHZ）作为流行病学研究的工具。
Multidrug-resistant (MDR) Klebsiella pneumoniae clinical isolates: a zone of high heterogeneity (HHZ) as a tool for epidemiological studies.
机构信息
Department of Biological Science, Center for Applied Biotechnology Studies, California State University Fullerton, Fullerton, CA 92831-3599, USA.
出版信息
Clin Microbiol Infect. 2012 Jul;18(7):E254-8. doi: 10.1111/j.1469-0691.2012.03886.x. Epub 2012 May 2.
Abstract
Comparison of genome-wide, high-resolution restriction maps of Klebsiella pneumoniae clinical isolates, including an NDM-1 producer, and in silico-generated restriction maps of sequenced genomes revealed a highly heterogeneous region we designated the 'high heterogeneity zone' (HHZ). The HHZ consists of several regions, including a 'hot spot' prone to insertions and other rearrangements. The HHZ is a characteristic genomic area that can be used in the identification and tracking of outbreak-causing strains.
摘要
比较了包括产 NDM-1 菌在内的几株肺炎克雷伯菌临床分离株的全基因组高分辨率限制图谱，以及通过对测序基因组进行计算机模拟生成的限制图谱，结果发现了一个高度异质的区域，我们将其命名为“高异质性区”（HHZ）。HHZ 由多个区域组成，包括一个容易发生插入和其他重排的“热点”。HHZ 是一个特征性的基因组区域，可用于鉴定和追踪引起暴发的菌株。
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