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Nosocomial outbreak of VIM-1-producing Klebsiella pneumoniae isolates of multilocus sequence type 15: molecular basis, clinical risk factors, and outcome.产 VIM-1 型肺炎克雷伯菌多位点序列型 15 医院感染暴发：分子基础、临床危险因素和结局。
Antimicrob Agents Chemother. 2012 Jan;56(1):420-7. doi: 10.1128/AAC.05036-11. Epub 2011 Oct 17.
2
Prospective genomic characterization of the German enterohemorrhagic Escherichia coli O104:H4 outbreak by rapid next generation sequencing technology.采用快速下一代测序技术对德国肠出血性大肠杆菌 O104:H4 暴发进行前瞻性基因组特征分析。
PLoS One. 2011;6(7):e22751. doi: 10.1371/journal.pone.0022751. Epub 2011 Jul 20.
3
Molecular analysis of population structure and antibiotic resistance of Klebsiella isolates from a three-year surveillance program in Florence hospitals, Italy.意大利佛罗伦萨医院三年监测项目中分离的肺炎克雷伯菌的种群结构和抗生素耐药性的分子分析。
Eur J Clin Microbiol Infect Dis. 2012 Mar;31(3):371-8. doi: 10.1007/s10096-011-1319-6. Epub 2011 Jul 9.
4
Increasing prevalence and dissemination of NDM-1 metallo-β-lactamase in India: data from the SMART study (2009).印度 NDM-1 金属β-内酰胺酶的流行率和传播率不断上升：来自 SMART 研究（2009 年）的数据。
J Antimicrob Chemother. 2011 Sep;66(9):1992-7. doi: 10.1093/jac/dkr240. Epub 2011 Jun 14.
5
Genomic analysis of Acinetobacter baumannii A118 by comparison of optical maps: identification of structures related to its susceptibility phenotype.利用光学图谱比较分析鲍曼不动杆菌 A118 的基因组：鉴定与其药敏表型相关的结构。
Antimicrob Agents Chemother. 2011 Apr;55(4):1520-6. doi: 10.1128/AAC.01595-10. Epub 2011 Jan 31.
6
Molecular characterization of the PhoPQ-PmrD-PmrAB mediated pathway regulating polymyxin B resistance in Klebsiella pneumoniae CG43.肺炎克雷伯菌 CG43 中多黏菌素 B 耐药性的 PhoPQ-PmrD-PmrAB 调控途径的分子特征。
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7
Evolution in quantum leaps: multiple combinatorial transfers of HPI and other genetic modules in Enterobacteriaceae.量子飞跃中的进化：肠杆菌科中 HPI 和其他遗传模块的多次组合转移。
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Genetic structure and distribution of the colibactin genomic island among members of the family Enterobacteriaceae.肠杆菌科成员中大肠杆菌素基因组岛的遗传结构与分布
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9
A new single-step quantitative pathogen detection system: template-tagging followed by multiplex asymmetric PCR using common primers and CE-SSCP.一种新型单步定量病原体检测系统：模板标记后使用通用引物进行多重不对称PCR及毛细管电泳-单链构象多态性分析
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10
Genome sequencing and comparative analysis of Klebsiella pneumoniae NTUH-K2044, a strain causing liver abscess and meningitis.肺炎克雷伯菌NTUH-K2044的基因组测序与比较分析，该菌株可引发肝脓肿和脑膜炎。
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耐多药（MDR）肺炎克雷伯菌临床分离株：高异质性区（HHZ）作为流行病学研究的工具。

Multidrug-resistant (MDR) Klebsiella pneumoniae clinical isolates: a zone of high heterogeneity (HHZ) as a tool for epidemiological studies.

机构信息

Department of Biological Science, Center for Applied Biotechnology Studies, California State University Fullerton, Fullerton, CA 92831-3599, USA.

出版信息

Clin Microbiol Infect. 2012 Jul;18(7):E254-8. doi: 10.1111/j.1469-0691.2012.03886.x. Epub 2012 May 2.

DOI:10.1111/j.1469-0691.2012.03886.x
PMID:22551038
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3377791/
Abstract

Comparison of genome-wide, high-resolution restriction maps of Klebsiella pneumoniae clinical isolates, including an NDM-1 producer, and in silico-generated restriction maps of sequenced genomes revealed a highly heterogeneous region we designated the 'high heterogeneity zone' (HHZ). The HHZ consists of several regions, including a 'hot spot' prone to insertions and other rearrangements. The HHZ is a characteristic genomic area that can be used in the identification and tracking of outbreak-causing strains.

摘要

比较了包括产 NDM-1 菌在内的几株肺炎克雷伯菌临床分离株的全基因组高分辨率限制图谱，以及通过对测序基因组进行计算机模拟生成的限制图谱，结果发现了一个高度异质的区域，我们将其命名为“高异质性区”（HHZ）。HHZ 由多个区域组成，包括一个容易发生插入和其他重排的“热点”。HHZ 是一个特征性的基因组区域，可用于鉴定和追踪引起暴发的菌株。