Meerson F Z, Abdikaliev N A, Kuznetsov V I, Kalvin'sh I Ia
Kardiologiia. 1990 Aug;30(8):69-72.
A higher vagal tone or its stimulation under certain conditions is known to increase the threshold of cardiac fibrillation and even to arrest developing arrhythmias. This effect is usually evaluated as a result of limiting the excessive adrenergic effect on the heart, which is observed in stress and ischemia. The following two facts have been first identified: 1) adaptation to moderate continuous stress may induce tonic excitation of parasympathetic regulation of the heart and enhance its resistance to ischemic and reperfusion arrhythmias; 2) this antiarrhythmic effect is completely reproducible by the recently synthesized acetylcholine analogue EDIHYP, ethyl-3/2-ethyl-2,2-dimethylhydrazinium/propionate iodate.
已知在某些情况下较高的迷走神经张力或其刺激会提高心脏颤动阈值，甚至能阻止正在发展的心律失常。这种效应通常被评估为是限制了应激和缺血时对心脏产生的过度肾上腺素能效应的结果。首次发现了以下两个事实：1）适应适度持续应激可能会诱发心脏副交感神经调节的紧张性兴奋，并增强其对缺血性和再灌注性心律失常的抵抗力；2）最近合成的乙酰胆碱类似物碘酸乙酯-3/2-乙基-2,2-二甲基肼基/丙酸盐（EDIHYP）可完全重现这种抗心律失常作用。
