Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Surg Obes Relat Dis. 2013 Sep-Oct;9(5):708-13. doi: 10.1016/j.soard.2012.02.011. Epub 2012 Mar 23.
Roux-en-Y gastric bypass surgery (RYGB) as treatment of morbid obesity results in substantial weight loss. Most published long-term studies have included few patients at the last follow-up point. The aim of the present study was to explore long-term results in a large cohort of patients 7-17 years after gastric bypass.
All 539 patients who had undergone primary RYGB from 1993 to 2003 at Uppsala and Örebro University Hospitals received a questionnaire regarding their postoperative status. Blood samples were obtained and the medical charts studied.
Of the 539 patients, 384 responded (71.2% response rate, mean age 37.9 yr, body mass index 44.5 kg/m(2) at surgery, 317 women, and 67 men). At a mean follow-up of 11.4 years (range 7-17), the body mass index had decreased to 32.5 kg/m(2), corresponding to an excess body mass index loss of 63.3%. Similar weight loss was observed, regardless of the length of follow-up. Orally treated diabetes resolved in 72% and sleep apnea and hyperlipidemia were improved. Revisional bariatric surgery had been performed in 2.1% and abdominoplasty in 40.2%. The gastrointestinal symptoms were considered tolerable. The overall result was satisfactory for 79% of the patients and 92% would recommend Roux-en-Y gastric bypass to a friend. Attendance to the annual checkups was 37%. Vitamin B12 supplements were taken by 72% and multivitamins by 24%.
At 11 years, substantial weight loss was maintained and revisional surgery was rare. Surprisingly few patients were compliant with the recommendation of lifelong supplements and yearly evaluations; however, patient satisfaction was high.
Roux-en-Y 胃旁路手术（RYGB）作为肥胖症的治疗方法可显著减轻体重。大多数已发表的长期研究仅在最后随访点纳入了少数患者。本研究旨在探讨胃旁路术后 7-17 年的大型队列患者的长期结果。
在乌普萨拉和厄勒布鲁大学医院接受原发性 RYGB 的 539 名患者均收到了一份关于其术后状况的问卷。采集了血样并研究了病历。
在 539 名患者中，有 384 名患者做出了回应（71.2%的回复率，平均年龄 37.9 岁，手术时的体重指数为 44.5kg/m²，女性 317 例，男性 67 例）。在平均 11.4 年（7-17 年）的随访中，体重指数降至 32.5kg/m²，多余体重指数减少了 63.3%。无论随访时间长短，都观察到了相似的减重效果。口服治疗的糖尿病缓解率为 72%，睡眠呼吸暂停和血脂异常得到改善。接受了 2.1%的再次减重手术和 40.2%的腹部整形术。胃肠道症状被认为是可耐受的。79%的患者对总体结果满意，92%的患者会向朋友推荐 Roux-en-Y 胃旁路术。只有 37%的患者参加了年度检查。72%的患者服用维生素 B12 补充剂，24%的患者服用多种维生素。
11 年后，体重仍显著减轻，再次手术的病例罕见。令人惊讶的是，只有少数患者遵守了终身补充剂和每年评估的建议；然而，患者满意度很高。
