Department of Neurosurgery, Temple University, Philadelphia, PA 19140, USA.
J Clin Neurosci. 2012 Jul;19(7):1029-31. doi: 10.1016/j.jocn.2011.12.002. Epub 2012 May 1.
We aimed to determine whether our targeting method for the subthalamic nucleus (STN) in Parkinson's disease informs the initial programming sequence. We evaluated 100 STN-lead pairs from 50 patients who underwent bilateral STN-deep brain stimulation operations. All patients had at least one year of follow-up. In each patient, we measured coordinates of the STN borders and determined the center from special T2-weighted MRI. We then measured the postoperative location of the lead tip by MRI registered to preoperative images. Finally, we determined the mode and active contact(s). Programming was monopolar 71% of the time. A total of 52% of left and 72% of right STN active contacts were located posterolateral to the STN center. In z, only 14% of the active contact(s) were >1mm below the STN center. Contacts 1 or 2 were active 90% of the time. The consistent location of active contacts suggests that initial programming began with contact 1 or 2.
我们旨在确定我们在帕金森病中对丘脑底核 (STN) 的靶向方法是否为初始编程序列提供了信息。我们评估了 50 名接受双侧 STN 深部脑刺激手术的患者的 100 对 STN 导联。所有患者均有至少一年的随访。在每位患者中，我们测量了 STN 边界的坐标，并从特殊的 T2 加权 MRI 中确定了中心。然后，我们通过与术前图像配准的 MRI 测量了导丝尖端的术后位置。最后，我们确定了模式和活动接触点。编程时 71%为单极。左 STN 的总共有 52%和右 STN 的 72%的活动接触点位于 STN 中心的后外侧。在 z 方向上，只有 14%的活动接触点位于 STN 中心下方 1 毫米以上。接触点 1 或 2 的活动时间占 90%。活动接触点的一致位置表明初始编程始于接触点 1 或 2。
