Section of Endocrinology, Andrology and Internal Medicine, Department of Medical and Pediatric Sciences, University of Catania, Catania, Italy.
Int J Impot Res. 2012 Jul-Aug;24(4):150-4. doi: 10.1038/ijir.2012.7. Epub 2012 May 3.
We have recently demonstrated the diagnostic value of a new immunophenotype of blood endothelial progenitor cells (EPCs=CD45neg/CD34pos/CD144pos) and endothelial microparticles (EMPs=CD45neg/CD144pos/AnnexinVpos) in patients with arterial erectile dysfunction (ED) according to severity of cavernous arterial insufficiency evaluated through penile Doppler. The aim of this study was to evaluate both EPCs and EMPs in patients with arterial ED and metabolic syndrome (MetS), comparing these patients with another group of patients without MetS and ED and a third group with MetS but without ED. For this study 50 patients with arterial ED and MetS were selected (age: 55.0±3.0 years; range: 47-60). A group of age-matched (age: 54.0±2.0 years; range: 44-60) patients without arterial ED and MetS (n=30), and another group of age-matched (age: 57.0±4.0 years; range: 40-62) patients with MetS but without ED (n=20) represented the control groups. EPCs and EMPs were significantly higher in patients compared with other groups (P<0.01). Both EPCs and EMPs correlated positively with the age, body mass index, and score of international index of ED (version five items) and with the following cavernous artery indices: peak systolic velocity, acceleration time and intima-media thickness. Among control groups patients with MetS but without ED showed serum concentrations of EPCs and EMPs significantly higher (P<0.05) compared with patients without MetS and ED. Patients with arterial ED and MetS have higher EPCs and EMPs compared with patients with MetS but without ED and patients without MetS and ED.
我们最近根据阴茎多普勒评估的海绵体动脉功能不全严重程度，证实了血液内皮祖细胞（EPC=CD45neg/CD34pos/CD144pos）和内皮微颗粒（EMP=CD45neg/CD144pos/AnnexinVpos）的新型免疫表型在动脉性勃起功能障碍（ED）患者中的诊断价值。本研究的目的是评估动脉性 ED 合并代谢综合征（MetS）患者的 EPC 和 EMP，并将这些患者与另一个无 MetS 和 ED 的患者组以及一个仅有 MetS 而无 ED 的患者组进行比较。为此，选择了 50 例动脉性 ED 合并 MetS 的患者（年龄：55.0±3.0 岁；范围：47-60 岁）。选择了年龄匹配（年龄：54.0±2.0 岁；范围：44-60 岁）、无动脉性 ED 和 MetS 的患者（n=30）和年龄匹配（年龄：57.0±4.0 岁；范围：40-62 岁）、无 ED 的 MetS 患者（n=20）作为对照组。与其他组相比，患者的 EPC 和 EMP 显著升高（P<0.01）。EPC 和 EMP 均与年龄、体重指数、国际勃起功能指数（五分量表）评分以及以下海绵体动脉指数呈正相关：收缩期峰值速度、加速时间和内-中膜厚度。在对照组中，无 ED 的 MetS 患者的 EPC 和 EMP 血清浓度明显高于无 MetS 和 ED 的患者（P<0.05）。与无 ED 的 MetS 患者和无 MetS 和 ED 的患者相比，动脉性 ED 合并 MetS 的患者的 EPC 和 EMP 更高。
