Institut de chimie moléculaire et des matériaux d'Orsay, Bât. 420, Université Paris-Sud 11, F-91405 Orsay cedex, France.
J Inorg Biochem. 2012 Jul;112:59-67. doi: 10.1016/j.jinorgbio.2012.02.030. Epub 2012 Mar 7.
A series of five new hexadentate tris-hydroxamate ligands based on a d-galactose or a glycerol scaffold have been synthesized. Protonation and ferric complex formation constants have been determined from solution studies by potentiometric and spectrophotometric titrations. All ligands form 1:1 Fe:L complexes. The calculated pFe values at pH 7.4 span over the range 19.2-23.0 depending on the scaffold and on the length of the spacers between hydroxamate and central scaffold and on the N-methyl substitution. This new kind of artificial siderophores based on a glycoscaffold is of interest as it opens up an easy way to modulate the pFe.
已合成了一系列基于半乳糖或甘油骨架的五个新型六齿三羟肟酸配体。通过电位滴定和分光光度滴定的溶液研究确定了质子化和铁络合形成常数。所有配体均形成 1:1 的 Fe:L 配合物。在 pH 7.4 时，计算出的 pFe 值范围为 19.2-23.0，具体取决于支架以及羟肟酸和中心支架之间间隔的长度和 N-甲基取代。这种基于糖支架的新型人工铁载体很有意义，因为它为调节 pFe 提供了一种简单的方法。
