儿童和青少年淋巴瘤亚型发病率：来自巴西的首次报告。

Lymphoma subtype incidence rates in children and adolescents: first report from Brazil.

机构信息

Coordenação de Prevenção e Vigilância, Instituto Nacional de Câncer, Rio de Janeiro, Brazil.

出版信息

Cancer Epidemiol. 2012 Aug;36(4):e221-6. doi: 10.1016/j.canep.2012.03.006. Epub 2012 May 1.

DOI:10.1016/j.canep.2012.03.006

PMID:22552334

Abstract

BACKGROUND

Lymphoma is the third most common pediatric malignancy. The purpose of this study was to analyze the incidence rates of lymphoma in children and adolescents in Brazil.

METHODS

All cases of Hodgkin lymphoma (HL), non-Hodgkin lymphoma (NHL), and Burkitt lymphoma (BL) were extracted from 14 population-based cancer registries (PBCRs) from 2000 to 2005, and included children and adolescents 0-19 years old. Analyses included age-adjusted incidence rates (AAIRs) and age-specific incidence rates (ASIRs) by each PBCR. A social exclusion index (SEI) was built and used as proxy for socioeconomic status (SES) levels. Correlations between SES and incidence rates were investigated using Spearman's test.

RESULTS

The median incidence of lymphoma was 22.7/million. AAIRs of lymphomas varied from 12.9 (Salvador) to 34.5 per million (São Paulo). Median AAIR was 8.8/million, 9.8/million, and 2.9/million for NHL, HL, and BL, respectively. In all PBCRs except that of Recife, AAIR was slightly higher in males than females. The median ASIR was highest for HL (18.5/million) at 15-19 years for both genders. For NHL there were two peaks for ASIR: 11.1/million (1-4 years of age) and 13.2/million (15-19 years of age). The median ASIR for BL was highest among children aged 1-4 years (4.7/million) and in males. Higher SEI correlated with higher incidence of HL (P = 0.06), whereas rates of NHL and BL did not correlate with SEI. Borderline different incidence rates were observed in HL correlated with cities with higher SEIs.

CONCLUSION

Incidence rates of lymphomas in Brazil do not differ compared to rates reported worldwide, although SES differences deserve further investigation.

摘要

背景

淋巴瘤是儿童中第三常见的恶性肿瘤。本研究旨在分析巴西儿童和青少年淋巴瘤的发病率。

方法

从 2000 年至 2005 年，从 14 个基于人群的癌症登记处（PBCR）中提取所有霍奇金淋巴瘤（HL）、非霍奇金淋巴瘤（NHL）和伯基特淋巴瘤（BL）病例，并纳入 0-19 岁的儿童和青少年。分析包括每个 PBCR 的年龄调整发病率（AAIR）和年龄特异性发病率（ASIR）。构建了一个社会排斥指数（SEI），并用作社会经济地位（SES）水平的替代指标。使用 Spearman 检验研究 SES 与发病率之间的相关性。

结果

淋巴瘤的中位数发病率为 22.7/百万。淋巴瘤的 AAIR 从萨尔瓦多的 12.9 到圣保罗的 34.5/百万不等。所有 PBCR 的中位数 AAIR 分别为 NHL 的 8.8/百万、HL 的 9.8/百万和 BL 的 2.9/百万。除累西腓外，所有 PBCR 中的男性 AAIR 略高于女性。HL 的中位数 ASIR 最高（18.5/百万），男女均为 15-19 岁。对于 NHL，ASIR 有两个高峰：11.1/百万（1-4 岁）和 13.2/百万（15-19 岁）。BL 的中位数 ASIR 最高的是 1-4 岁的儿童（4.7/百万）和男性。较高的 SEI 与 HL 发病率较高相关（P=0.06），而 NHL 和 BL 的发病率与 SEI 无关。HL 与 SEI 较高的城市相关的发病率略有不同。