Research Center, School of Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Braz J Infect Dis. 2012 Mar-Apr;16(2):204-8.
Atypical fast-growing Mycobacterium species are usually identified after laser-assisted in situ keratomileusis, cosmetic surgeries, and catheter-related, pulmonary or soft tissue infections. We herein present the case of a 56-year-old man with purulent discharge, redness, and foreign body sensation in his left eye. He underwent two surgeries that partially controlled the infection but were not curative. Corneal transplantation was performed, and a biopsy of the excised cornea indicated Mycobacterium aurum infection, which was confirmed by polymerase chain reaction-restriction fragment length polymorphism analysis. This appears to be the first documented case of keratitis attributable to the non-tuberculous mycobateria M. aurum. The intractable extra-ocular progression of the disease in the absence of general signs or symptoms was notable. We suggest considering non-tuberculous mycobacteria among the probable causes of complicated keratitis or keratitis that does not respond to drug treatment, especially in regions where tuberculosis is endemic.
非典型快速生长分枝杆菌通常在激光辅助原位角膜磨镶术、美容手术以及与导管相关的肺部或软组织感染后被鉴定。我们在此报告一例 56 岁男性患者，左眼出现脓性分泌物、红肿和异物感。他接受了两次手术，部分控制了感染，但未能治愈。进行了角膜移植，切除的角膜活检显示金黄色葡萄球菌感染，聚合酶链反应-限制性片段长度多态性分析证实了这一点。这似乎是首例可归因于非结核分枝杆菌金黄色葡萄球菌的角膜炎病例。值得注意的是，在没有全身症状或体征的情况下，疾病的难治性眼外进展。我们建议在结核病流行地区，特别是在考虑复杂角膜炎或药物治疗无效的角膜炎时，将非结核分枝杆菌作为可能的病因之一。
