Bravo Laura, Fernández Anabel, Núñez Fidel Á, Rivero Luis A, Ramírez Margarita, Aguila Adalberto, Ledo Yudith, Cruz Yanaika, Hernández Jenny
Hospital Dr Salvador Allende, La Habana, Cuba.
Rev Chilena Infectol. 2012 Feb;29(1):44-8. doi: 10.4067/S0716-10182012000100008. Epub 2012 Apr 10.
The members of the genus Aeromonas are currently considered important gastrointestinal pathogens in different geographical areas. From February 1985 to January 2005 several case-control studies were coordinated by the National Reference Laboratory for Diarrheal Diseases from the Pedro Kouri Institute. The study purpose was to analyze a possible pathogenic role for Aeromonas spp in Cuban children with acute diarrhea. In that period 2,322 children less than 5 years old with acute diarrhea were studied for diarhoeal pathogens and another group of 2,072 non hospitalized children without diarrhea during the similar time from the same geographical areas and matched by ages were recruited. In the group of children with diarrheas (cases), Aeromonas spp. was isolated in 166 (7.15%) and in the control group the microorganism was found in only 35 (1.76%). When Aeromonas isolation rates were compared between both groups, we found that probability to isolate this specie was significantly higher in cases than in controls (OR = 4.48, 95% IC: 3.05-6.60; P < 0.001). The Aeromonas species more frequently isolated were A. caviae, A. hydrophila, and A. veronii bv sobria. Other enteric pathogens detected in children with diarrhea were: Shigella spp in 418 (18%) (P < 0.0001), Salmonella spp in 53 (2.3%) (P < 0.01), and enteropathogenic E. coli in 58 (2.49%) (P < 0.05).
气单胞菌属成员目前被认为是不同地理区域重要的胃肠道病原体。1985年2月至2005年1月，佩德罗·库里研究所腹泻病国家参考实验室协调开展了多项病例对照研究。研究目的是分析气单胞菌属在古巴急性腹泻儿童中可能的致病作用。在该时期，对2322名5岁以下急性腹泻儿童进行了腹泻病原体研究，并从同一地理区域招募了另一组2072名年龄匹配的无腹泻非住院儿童作为对照。在腹泻儿童组（病例组）中，分离出气单胞菌属的有166例（7.15%），而在对照组中仅35例（1.76%）检测到该微生物。比较两组气单胞菌分离率时，我们发现病例组分离出该菌的概率显著高于对照组（比值比=4.48，95%可信区间：3.05 - 6.60；P<0.001）。最常分离出的气单胞菌种类为豚鼠气单胞菌、嗜水气单胞菌和温和气单胞菌。腹泻儿童中检测到的其他肠道病原体为：志贺菌属418例（18%）（P<0.0001），沙门菌属53例（2.3%）（P<0.01），致病性大肠杆菌58例（2.49%）（P<0.05）。
