水泡性口炎病毒的转录对于关闭细胞RNA合成是必需的。
Transcription of vesicular stomatitis virus is required to shut off cellular RNA synthesis.
作者信息
Weck P K, Wagner R R
出版信息
J Virol. 1979 Apr;30(1):410-3. doi: 10.1128/JVI.30.1.410-413.1979.
Abstract
RNA synthesis by mouse myeloma (MPC-11) cells was rapidly and progressively shut off by infection with vesicular stomatitis virus temperature-sensitive (ts) mutants permissive for transcription. In sharp contrast, mutants or defective vesicular stomatitis virions restricted in transcription were incapable of causing progressive inhibition of cellular RNA synthesis even at massive multiplicities of infection. A viral product synthesized 30 to 60 min after permissive infection with tsG114(I) appeared to be essential for prolonged inhibition of RNA synthesis in cells switched up to restrictive temperature.
摘要
感染允许转录的水泡性口炎病毒温度敏感（ts）突变体后，小鼠骨髓瘤（MPC - 11）细胞的RNA合成迅速且逐渐被关闭。与之形成鲜明对比的是，转录受限的突变体或缺陷型水泡性口炎病毒粒子，即使在大量感染复数的情况下，也无法对细胞RNA合成造成渐进性抑制。在允许温度下感染tsG114(I) 30至60分钟后合成的一种病毒产物，似乎是在切换到限制温度的细胞中长时间抑制RNA合成所必需的。
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