Byrjalsen I, Riis B J, Christiansen C
Department of Clinical Chemistry, University of Copenhagen, Glostrup Hospital, Denmark.
Maturitas. 1990 Jun;12(2):79-88. doi: 10.1016/0378-5122(90)90085-k.
In view of the increasing use of oestrogen-progestogen therapy in post-menopausal women the availability of possible biochemical marker of endometrial response to progestogen would be highly desirable. Placental protein 14 (PP14) has recently been shown to be excreted from the endometrium during the secretory phase of the menstrual cycle. In the present study we examined the concentration of serum PP14 (S-PP14) in 15 pre-menopausal women during the menstrual cycle and in 30 early post-menopausal women receiving three different doses of 17 beta-oestradiol (E2), cyclically combined with norethisterone acetate (NETA). S-PP14 levels peaked on day 1 following the onset of menstrual bleeding and on day 7 during NETA administration. It was possible to estimate the area under the S-PP14 curve reliably from one or two blood samples taken at optimal times. In the post-menopausal women, S-PP14 varied in a highly significant dose-dependent manner, i.e., the higher the E2 dose (in relation to the fixed NETA dose) the higher the S-PP14 response was found to be. We suggest that S-PP14 measurements might reflect the quantitative development of the endometrium in the secretory phase in both pre-menopausal and post-menopausal women.
鉴于绝经后妇女越来越多地使用雌激素 - 孕激素疗法，若能找到子宫内膜对孕激素反应的生化标志物将非常理想。胎盘蛋白14（PP14）最近被发现会在月经周期的分泌期从子宫内膜排出。在本研究中，我们检测了15名绝经前妇女在月经周期中的血清PP14（S - PP14）浓度，以及30名接受三种不同剂量17β - 雌二醇（E2）与醋酸炔诺酮（NETA）周期性联合治疗的绝经后早期妇女的S - PP14浓度。S - PP14水平在月经出血开始后的第1天以及NETA给药期间的第7天达到峰值。从在最佳时间采集的一两个血样中可以可靠地估算出S - PP14曲线下的面积。在绝经后妇女中，S - PP14呈现出高度显著的剂量依赖性变化，即E2剂量越高（相对于固定的NETA剂量），S - PP14反应越高。我们认为，测量S - PP14可能反映绝经前和绝经后妇女分泌期子宫内膜的定量变化。
