Seppälä M, Alfthan H, Vartiainen E, Stenman U H
Department I of Obstetrics and Gynaecology, Helsinki University Central Hospital, Finland.
Hum Reprod. 1987 Nov;2(8):741-3. doi: 10.1093/oxfordjournals.humrep.a136624.
The effect of cyclical oestrogen-progestogen replacement on the levels of endometrial secretory protein PP14 (placental protein 14) was studied in 39 post-menopausal women, 13 of whom had had a hysterectomy. In those women with an intact uterus, the average rise of the late luteal phase serum PP14 concentration was from 29 to 45 micrograms/l, a 55% rise (P less than 0.001). Only a slight rise (from 27 to 30 micrograms/l) was observed in hysterectomized women. Cyclical replacement with oestrogen and levonorgestrel caused a greater rise in serum PP14 level than did replacement with the same dose of oestrogen plus medroxyprogesterone acetate (P less than 0.05). Because PP14 is found also in the serum of hysterectomized post-menopausal women, the uterus cannot be the only source of circulating PP14. But, the difference between hysterectomized and non-hysterectomized women indicates that the quiescent post-menopausal uterus responds to oestrogen-progestogen replacement by increased PP14 secretion, which can be detected and quantified by a blood test. The measurement of PP14 in serum may also become useful for testing the effect of various progestogens.
对39名绝经后女性进行了研究，以探讨周期性雌激素 - 孕激素替代疗法对子宫内膜分泌蛋白PP14（胎盘蛋白14）水平的影响，其中13名女性已接受子宫切除术。在子宫完整的女性中，黄体晚期血清PP14浓度平均从29微克/升升至45微克/升，上升了55%（P<0.001）。在接受子宫切除的女性中，仅观察到轻微上升（从27微克/升升至30微克/升）。与相同剂量的雌激素加醋酸甲羟孕酮相比，雌激素和左炔诺孕酮的周期性替代导致血清PP14水平升高幅度更大（P<0.05）。由于在绝经后接受子宫切除的女性血清中也发现了PP14，子宫不可能是循环中PP14的唯一来源。但是，接受子宫切除和未接受子宫切除的女性之间的差异表明，静止的绝经后子宫对雌激素 - 孕激素替代疗法的反应是增加PP14分泌，这可以通过血液检测来检测和量化。血清中PP14的测量对于测试各种孕激素的效果也可能变得有用。
