Seeber A, Kiesswetter E, Neidhart B, Blaszkewicz M
Institute of Occupational Health, University of Dortmund, FRG.
Neurotoxicol Teratol. 1990 Nov-Dec;12(6):653-5. doi: 10.1016/0892-0362(90)90080-v.
Employees of a factory producing antiknock additives for gasoline were examined psychologically after an exposure of an average of 14 years. A neurobehavioral symptom questionnaire, tests of single and choice reaction time, a cancellation task and a digit symbol test were the neurobehavioral variables. Total lead in urine and trimethyllead in urine showed different patterns of correlation with the neurobehavioral measures. Intellectual abilities (logical reasoning), age, and job years were controlled by partial correlation statistics as possible confounders. Referring to the low level of 21 micrograms lead per 100 ml blood and regarding the dose-response relations reported in the literature, the results support the hypothesis of a special neurotoxicity of the alkyllead compounds.
对一家生产汽油抗爆添加剂工厂的员工进行了心理检查，这些员工平均接触该添加剂14年。神经行为变量包括一份神经行为症状问卷、单反应和选择反应时测试、一项划消任务以及一项数字符号测试。尿中总铅和尿中三甲基铅与神经行为测量指标呈现出不同的相关模式。通过偏相关统计控制智力能力（逻辑推理）、年龄和工作年限，将其作为可能的混杂因素。鉴于每100毫升血液中铅含量为21微克的低水平，并参考文献中报道的剂量反应关系，这些结果支持烷基铅化合物具有特殊神经毒性这一假设。
