虎皮鹦鹉（Melopsittacus undulatus）基因组中的内源性嗜肝 DNA 病毒和禽嗜肝 DNA 病毒的进化。
Endogenous hepadnaviruses in the genome of the budgerigar (Melopsittacus undulatus) and the evolution of avian hepadnaviruses.
机构信息
Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, PA, USA.
出版信息
J Virol. 2012 Jul;86(14):7688-91. doi: 10.1128/JVI.00769-12. Epub 2012 May 2.
Abstract
Endogenous hepadnaviruses (hepatitis B viruses [HBVs]) were recently discovered in the genomes of passerine birds. We mined six additional avian genomes and discovered multiple copies of endogenous HBVs in the budgerigar (order Psittaciformes), designated eBHBV. A phylogenetic analysis reveals that the endogenous hepadnaviruses are more diverse than their exogenous counterparts and that the endogenous and exogenous hepadnaviruses form distinct lineages even when sampled from the same avian order, indicative of multiple genomic integration events.
摘要
内源性嗜肝 DNA 病毒（乙型肝炎病毒 [HBV]）最近在雀形目鸟类的基因组中被发现。我们对另外六个鸟类基因组进行了挖掘，在虎皮鹦鹉（鹦鹉目）中发现了多个内源性 HBV 拷贝，被命名为 eBHBV。系统发育分析表明，内源性嗜肝 DNA 病毒比其外源性对应物更为多样化，即使从同一鸟类目采样，内源性和外源性嗜肝 DNA 病毒也形成不同的谱系，表明有多次基因组整合事件。
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