Song Yin-Wei, Yu Ai-Hua, Cai Xiao-Jun
Department of Ophthalmology, Zhongnan Hospital of Wuhan University, Wuhan 430072, Hubei Province, China.
Int J Ophthalmol. 2010;3(4):352-5. doi: 10.3980/j.issn.2222-3959.2010.04.18. Epub 2010 Dec 18.
To evaluate the recurrence rate and safety of amniotic membrane transplantation (AMT) augmented with mitomycin C (MMC) compared with amniotic membrane transplantation alone during the pterygium excision.
We took a meta-analysis on this program. Pertinent studies were selected through extensive searches of the Cochrane Library, MEDLINE, EMBASE, CBMdisc, CNKI. Pooled estimates were carried out in RevMan software v.4.2.
Six trials reported postoperative recurrence rate of pterygium, included 882 eyes, three trials reported the complications. The results of meta-analysis showed that recurrence rate of AMT plus MMC group was 5.41%, AMT alone group was 16.89%, RR was 0.32, 95%CI ranged from 0.19 to 0.56, Z was 4.06, P<0.001. Two trials reported early complication as punctata keratitis, the incidence rate of AMT plus MMC group and AMT alone group were 17.14% and 0.00%, RR was 12.11, 95%CI ranged from 1.62 to 90.76.
Amniotic membrane transplantation with MMC was associated with lower recurrence rate compared with amniotic membrane transplantation alone in pterygium excision, whether accompanied a higher risk with adverse events need more investigation.
评估在翼状胬肉切除术中，与单纯羊膜移植相比，丝裂霉素C（MMC）辅助羊膜移植（AMT）的复发率和安全性。
我们对该方案进行了荟萃分析。通过广泛检索Cochrane图书馆、MEDLINE、EMBASE、CBMdisc、CNKI来选择相关研究。在RevMan软件v.4.2中进行合并估计。
六项试验报告了翼状胬肉术后复发率，涉及882只眼，三项试验报告了并发症。荟萃分析结果显示，AMT联合MMC组的复发率为5.41%，单纯AMT组为16.89%，RR为0.32，95%CI为0.19至0.56，Z为4.06，P<0.001。两项试验报告早期并发症为点状角膜炎，AMT联合MMC组和单纯AMT组的发生率分别为17.14%和0.00%，RR为12.11，95%CI为1.62至90.76。
在翼状胬肉切除术中，与单纯羊膜移植相比，MMC辅助羊膜移植的复发率较低，是否伴有更高的不良事件风险需要更多研究。
