羊膜移植对10例碱烧伤患者角膜新生血管化的影响。
Effect of amnion membrane transplantation on corneal neovascularization in 10 patients with alkali burn.
作者信息
Yin Lan, Pi Yu-Li
机构信息
Department of Ophthalmology, the First Affiliated Hospital of General Hospital of PLA, Beijing 100048, China.
出版信息
Int J Ophthalmol. 2011;4(1):110-1. doi: 10.3980/j.issn.2222-3959.2011.01.25. Epub 2011 Feb 18.
By observing clinical cases, we studied the curative effect of amnion membrane transplantation on decreasing corneal neovascularization (CNV). It was a non-randomized retrospective case-control study. Among 17 cases (21 eyes) of third-degree alkali burns from 2007 to 2010, 10 cases (12 eyes) were performed with amnion membrane transplantation operation, and others were not. Amnion membrane transplantation was performed at the 3(rd) day after burn in the treatment group. Areas of CNV in double groups were measured at the 14(th) day and 60(th) day after burn. Area of CNV in the treatment group was (66.207±7.251)mm(2) at the 14(th) day after burn, and was 18.27% lower than that in the control group. Area of CNV in the treatment group was (120.046±13.812)mm(2) at the 60(th) day after burn, and was 11.35% lower than that in the control group. There was both statistical significance (P<0.05). Amnion membrane transplantation operation can inhibit the growth of corneal neovascularization induced by alkali burn.
通过观察临床病例，我们研究了羊膜移植对减少角膜新生血管（CNV）的疗效。这是一项非随机回顾性病例对照研究。在2007年至2010年的17例（21眼）三度碱烧伤患者中，10例（12眼）接受了羊膜移植手术，其余未接受。治疗组在烧伤后第3天进行羊膜移植。在烧伤后第14天和第60天测量两组的CNV面积。治疗组烧伤后第14天的CNV面积为（66.207±7.251）mm²，比对照组低18.27%。治疗组烧伤后第60天的CNV面积为（120.046±13.812）mm²，比对照组低11.35%。两者均有统计学意义（P<0.05）。羊膜移植手术可抑制碱烧伤诱导的角膜新生血管生长。
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