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HIV 暴露但未感染的婴儿在生命的第一年有发生严重感染的风险增加。

HIV-exposed uninfected infants are at increased risk for severe infections in the first year of life.

机构信息

Department of Paediatrics and Child Health, Stellenbosch University, Stellenbosch, South Africa.

出版信息

J Trop Pediatr. 2012 Dec;58(6):505-8. doi: 10.1093/tropej/fms019. Epub 2012 May 3.

DOI:10.1093/tropej/fms019
PMID:22555385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3612013/
Abstract

HIV-exposed uninfected (HEU) infants have higher infectious morbidity than HIV-unexposed uninfected (HUU) infants. We present the clinical outcomes from a pilot cohort study of 27 HEU and 28 HUU infants. In the absence of infant malnutrition or advanced maternal HIV, HEU infants experienced a 2.74 (0.85-8.78) times greater risk of hospitalization in the first year.

摘要

HIV 暴露未感染（HEU）婴儿的传染性发病率高于 HIV 未暴露未感染（HUU）婴儿。我们报告了一项针对 27 名 HEU 和 28 名 HUU 婴儿的试点队列研究的临床结果。在没有婴儿营养不良或晚期母婴 HIV 的情况下，HEU 婴儿在第一年住院的风险增加了 2.74 倍（0.85-8.78）。

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J Acquir Immune Defic Syndr. 2010 Jan;53(1):6-13. doi: 10.1097/QAI.0b013e3181bd5a47.
3
Early weaning of HIV-exposed uninfected infants and risk of serious gastroenteritis: Findings from two perinatal HIV prevention trials in Kampala, Uganda.暴露于HIV但未感染婴儿的早期断奶与严重肠胃炎风险：乌干达坎帕拉两项围产期HIV预防试验的结果
J Acquir Immune Defic Syndr. 2010 Jan;53(1):20-7. doi: 10.1097/QAI.0b013e3181bdf68e.
4
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Pediatr Infect Dis J. 2007 Jun;26(6):519-26. doi: 10.1097/01.inf.0000264527.69954.4c.
5
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Lancet. 2000 Feb 5;355(9202):451-5.