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前庭诊断与治疗的展望。

Perspectives in vestibular diagnostics and therapy.

作者信息

Ernst Arneborg

机构信息

HNO-Klinik, Unfallkrankenhaus Berlin, Germany.

出版信息

GMS Curr Top Otorhinolaryngol Head Neck Surg. 2011;10:Doc05. doi: 10.3205/cto000078. Epub 2012 Apr 26.

DOI:10.3205/cto000078
PMID:22558055
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3341582/
Abstract

Vestibular diagnostics and therapy ist the mirror of technological, scientific and socio-economics trends as are other fields of clinical medicine. These trends have led to a substantial diversification of the field of neurotology.The improvements in diagnostics have been characterized by the introduction of new receptor testing tools (e.g., VEMPs), progress in imaging (e.g., the endolymphatic hydrops) and in the description of central-vestibular neuroplasticity. The etiopathology of vestibular disorders has been updated by geneticists (e.g., the description of the COCH gene mutations), the detection of structural abnormalities (e.g., dehiscence syndromes) and related disorders (e.g. migraine-associated vertigo). The therapeutic options were extended by re-evaluation of techniques known a long time ago (e.g., saccus exposure), the development of new approaches (e.g., dehiscence repair) and the introduction of new drug therapy concepts (e.g., local drug delivery). Implantable, neuroprosthetic solutions have not yet reached experimental safety and validity and are still far away. However, externally worn neuroprosthetic solution were introduced in the rehab of vestibular disorders (e.g., VertiGuard system).These and related trends point into a medical future which is characterized by presbyvertigo as classical sign of the demographic changes ahead, by shortage of financial resources and a medico-legally over-regulated, even hostile environment for physicians in clinical medicine.

摘要

前庭诊断与治疗如同临床医学的其他领域一样,是技术、科学和社会经济趋势的反映。这些趋势导致了神经耳科学领域的大幅多样化。诊断方面的进展表现为新受体检测工具(如视频眼震图)的引入、成像技术的进步(如内淋巴积水)以及中枢前庭神经可塑性描述的进展。前庭疾病的病因病理学已因遗传学家(如COCH基因突变的描述)、结构异常(如裂隙综合征)及相关疾病(如偏头痛相关性眩晕)的发现而得到更新。治疗选择通过对早就为人所知的技术(如囊暴露)的重新评估、新方法(如裂隙修复)的开发以及新药物治疗概念(如局部药物递送)的引入而得以扩展。可植入的神经假体解决方案尚未达到实验安全性和有效性,仍有很大差距。然而,外部佩戴的神经假体解决方案已被引入前庭疾病的康复治疗(如VertiGuard系统)。这些及相关趋势指向一个医学未来,其特征是老年眩晕作为即将到来的人口结构变化的典型标志、财政资源短缺以及临床医学领域对医生而言医疗法律监管过度甚至充满敌意的环境。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/3341582/b6470f83e357/CTO-10-05-g-005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/3341582/ab7d5c5a659d/CTO-10-05-t-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/3341582/b025c8b9f180/CTO-10-05-g-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/3341582/c643535df6cf/CTO-10-05-g-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/3341582/928c31c7d49d/CTO-10-05-g-003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/3341582/ad252be09cb2/CTO-10-05-g-004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/3341582/b6470f83e357/CTO-10-05-g-005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/3341582/ab7d5c5a659d/CTO-10-05-t-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/3341582/b025c8b9f180/CTO-10-05-g-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/3341582/c643535df6cf/CTO-10-05-g-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/3341582/928c31c7d49d/CTO-10-05-g-003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/3341582/ad252be09cb2/CTO-10-05-g-004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d4f/3341582/b6470f83e357/CTO-10-05-g-005.jpg

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本文引用的文献

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Voxel-based morphometry depicts central compensation after vestibular neuritis.基于体素的形态测量学描绘了前庭神经炎后的中枢代偿。
Ann Neurol. 2010 Aug;68(2):241-9. doi: 10.1002/ana.22063.
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10-year review of endolymphatic sac surgery for intractable meniere disease.顽固性梅尼埃病的内淋巴囊手术 10 年回顾。
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Geriatric vestibulopathy assessment and management.老年前庭病的评估与管理。
Curr Opin Otolaryngol Head Neck Surg. 2010 Oct;18(5):386-91. doi: 10.1097/MOO.0b013e32833ce5a6.
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Frequency and diagnostic utility of intralabyrinthine FLAIR hyperintensity in the evaluation of internal auditory canal and inner ear pathology.评估内听道和内耳病变时内淋巴管 FLAIR 高信号的频率和诊断效用。
Acad Radiol. 2010 Aug;17(8):992-1000. doi: 10.1016/j.acra.2010.04.002.
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Potential solutions to several vestibular challenges facing clinicians.解决临床医生面临的几个前庭挑战的潜在方法。
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Stroke. 2010 Jul;41(7):1558-60. doi: 10.1161/STROKEAHA.110.582783. Epub 2010 May 20.
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Dynamic visual acuity during head-thrust test in canal planes in healthy subjects and patients with vestibular neuritis.健康受试者和前庭神经炎患者在半规管平面进行摇头试验时的动态视力。
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