Ozturk A B, Celebioglu E, Karakaya G, Kalyoncu A F
Hacettepe University, School of Medicine, Department of Chest Disease, Adult Allergy Unit, 06100 Ankara, Turkey.
Allergol Immunopathol (Madr). 2013 May-Jun;41(3):189-93. doi: 10.1016/j.aller.2012.01.007. Epub 2012 May 3.
Drug provocation tests (DPTs) need technical equipment, staff and time. There are very few allergy centres performing DPTs in Turkey. Therefore many patients are referred to these centres. One day triple-double antibiotic or non-steroidal anti-inflammatory drug (NSAID) oral DPT for determining safe alternatives is safe, cost-effective and time saving compared to conventional one day one drug oral DPT. Our aim was to investigate the safety of antibiotic-NSAID oral DPT performed on the same day to find safe alternatives in multidrug hypersensitive patients.
Forty-two patients who had been diagnosed as having both antibiotic and NSAID hypersensitivity were enrolled to the study between 15 November and 15 July 2010. The reactions were urticaria and/or angio-oedema not including laryngeal oedema for all patients. Two antibiotics-one NSAID or two NSAIDs-one antibiotic triple test have been performed on the same day to study patients (n=22), while the control group (n=20) had taken drugs on three separate days.
Only two patients had positive reactions during triple test and two patients had adverse reactions; one had gastric pain, one had nausea. Three patients in the control group had positive reactions. There were no significant differences between the two groups in frequency of adverse and allergic drug reactions (p>0.05). Sixty days were spent for the tests of the control group with only 28 days for the study population.
Triple test performed with antibiotic and NSAID on the same day for determining safe alternatives for multidrug hypersensitive patients reporting non-life-threatening allergic reactions seems to be safe and time-saving.
药物激发试验（DPTs）需要技术设备、工作人员和时间。在土耳其，进行药物激发试验的过敏中心非常少。因此，许多患者被转诊到这些中心。与传统的单日单药口服激发试验相比，用于确定安全替代药物的一日三联双倍剂量抗生素或非甾体抗炎药（NSAID）口服激发试验是安全、经济高效且节省时间的。我们的目的是研究在同一天进行抗生素 - NSAID口服激发试验以在多种药物过敏患者中寻找安全替代药物的安全性。
2010年11月15日至7月15日期间，42名被诊断为对抗生素和NSAID均过敏的患者纳入本研究。所有患者的反应均为荨麻疹和/或血管性水肿，不包括喉部水肿。对患者（n = 22）在同一天进行两种抗生素 - 一种NSAID或两种NSAID - 一种抗生素的三联试验，而对照组（n = 20）在三个不同的日子服药。
三联试验期间只有两名患者出现阳性反应，两名患者出现不良反应；一名患者胃痛，一名患者恶心。对照组有三名患者出现阳性反应。两组在药物不良反应和过敏反应的发生率上无显著差异（p>0.05）。对照组的试验花费了60天，而研究人群仅花费了28天。
对于报告无危及生命过敏反应的多种药物过敏患者，同一天进行抗生素和NSAID的三联试验以确定安全替代药物似乎是安全且节省时间的。
