Department of Dermatology, Duke University, DUMC 3135, Durham, NC 27710, USA.
Immunol Allergy Clin North Am. 2012 May;32(2):263-74, vi. doi: 10.1016/j.iac.2012.04.006.
Dermatitis herpetiformis (DH) is an autoimmune blistering skin disease in which antigen presentation in the gastrointestinal mucosa results in cutaneous IgA deposition and distinct, neutrophil-driven cutaneous lesions. Our findings suggest that the qualitatively different immune response to gluten in the intestinal mucosa of patients with DH results in minimal clinical symptoms, allowing the continued ingestion of gluten and the eventual development of DH. Our model may provide a new way to understand the pathogenesis of other skin diseases associated with gastrointestinal inflammation such as pyoderma gangrenosum or erythema nodosum, or explain association of seronegative inflammatory arthritis with inflammatory bowel disease.
疱疹样皮炎（DH）是一种自身免疫性水疱性皮肤病，其中胃肠道黏膜中的抗原呈递导致皮肤 IgA 沉积和独特的、中性粒细胞驱动的皮肤损伤。我们的研究结果表明，DH 患者肠道黏膜中对 gluten 的免疫反应具有不同的性质，导致临床症状轻微，允许继续摄入 gluten，并最终发展为 DH。我们的模型可能为理解其他与胃肠道炎症相关的皮肤病（如坏疽性脓皮病或结节性红斑）的发病机制提供新的途径，或解释血清阴性炎症性关节炎与炎症性肠病的关联。
