St George Hospital, Kogarah, Sydney, NSW 2217, Australia.
Immunol Allergy Clin North Am. 2012 May;32(2):283-94, vii. doi: 10.1016/j.iac.2012.04.008. Epub 2012 Apr 18.
Corticosteroids, while providing rapid remission and ongoing control of symptoms of autoimmune blistering diseases (AIBD), have numerous potentially serious acute and long-term side effects. Evidence-based medicine has reevaluated the various types of corticosteroids and forms of corticosteroid delivery in AIBD to ascertain whether any advantages of specific delivery systems or regimens exist. Careful monitoring of patients and simple preventive measures are effective in minimizing the adverse outcomes associated with their use. This article outlines the current level of evidence for corticosteroid use in AIBDs, and discusses appropriate investigations and interventions to minimize or prevent the associated adverse effects.
皮质类固醇虽然能迅速缓解并持续控制自身免疫性水疱病 (AIBD) 的症状，但也有许多潜在的严重急性和长期副作用。循证医学重新评估了 AIBD 中各种类型的皮质类固醇和皮质类固醇给药方式，以确定是否存在特定给药系统或方案的任何优势。仔细监测患者并采取简单的预防措施，可有效降低与使用相关的不良后果。本文概述了皮质类固醇在 AIBD 中的当前证据水平，并讨论了适当的检查和干预措施，以最小化或预防相关的不良反应。
