霉酚酸酯治疗自身免疫性大疱性疾病。
Mycophenolate mofetil for the management of autoimmune bullous diseases.
机构信息
Department of Dermatology, Rabin Medical Center, Beilinson Campus, Jabotinski Street 39, Petah Tiqwa 49100, Israel.
出版信息
Immunol Allergy Clin North Am. 2012 May;32(2):309-15, vii. doi: 10.1016/j.iac.2012.04.010. Epub 2012 Apr 18.
Immunosuppressive agents such as azathioprine, cyclophosphamide, and mycophenolate mofetil (MMF) are now widely used in the treatment of autoimmune bullous diseases. This article reviews the use of MMF for the treatment of several bullous conditions, and assesses the evidence gathered from clinical trials and case series. According to numerous case series, MMF could be of value in treating refractory disease. The few randomized clinical trials conducted to date of patients with pemphigus and bullous pemphigoid report a similar efficacy for MMF to other immunosuppressants.
免疫抑制剂如硫唑嘌呤、环磷酰胺和霉酚酸酯（MMF）目前广泛用于治疗自身免疫性大疱性疾病。本文综述了 MMF 治疗几种大疱性疾病的应用，并评估了来自临床试验和病例系列的证据。根据大量的病例系列，MMF 可能对治疗难治性疾病有价值。迄今为止，针对天疱疮和大疱性类天疱疮患者进行的少数随机临床试验报告，MMF 的疗效与其他免疫抑制剂相似。
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