Instituto de Neurociencias CSIC-UMH, Avda Ramón y Cajal s/n, San Juan de Alicante, 03550, Spain; UMR 444, INRA-ENVT, Génétique Cellulaire, Toulouse, France.
Curr Opin Genet Dev. 2012 Aug;22(4):308-14. doi: 10.1016/j.gde.2012.03.004. Epub 2012 May 5.
Early embryonic territories are transient entities under permanent remodelling to form newly derived cell populations that will eventually give rise to the adult tissues and organs. A vast effort has been devoted to identifying the determinants and mechanisms that define embryonic territories. Indeed, studies in the vertebrate embryo from the morula stage to the segregation of the main embryonic layers-ectoderm, mesoderm and endoderm-have highlighted the importance of the mutual exclusion/repression between pairs of transcription factors, in coordination with the control exerted over cell division, adhesion and motility.
早期胚胎区域是不断重塑的瞬态实体，以形成新衍生的细胞群体，最终将产生成体组织和器官。人们付出了巨大努力来确定定义胚胎区域的决定因素和机制。事实上，从桑葚胚阶段到主要胚胎层（外胚层、中胚层和内胚层）分离的脊椎动物胚胎研究强调了转录因子对细胞分裂、黏附和运动的控制下，相互排斥/抑制的重要性。
