Center for Joint Preservation and Replacement, Rubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, Baltimore, Maryland, USA.
J Arthroplasty. 2012 Oct;27(9):1663-1668.e1. doi: 10.1016/j.arth.2012.03.035. Epub 2012 May 4.
Histopathologic analysis of frozen tissue samples is used to aid the intraoperative diagnosis of periprosthetic hip infections, but there are concerns about reliability. The purposes of this study were to determine the rate of concordance between diagnoses of infection made with frozen and permanent sections and to assess how discrepancies affected patient outcomes. A total of 282 samples from 62 patients were collected for frozen and permanent section analysis. There was concordance in 274 samples (97%). In 1 case, discrepancies led to retention of components during persistent infection, and the patient required further revision and antibiotics until infection free. Otherwise, discrepancies did not affect patient outcomes. There is good concordance between frozen and permanent sections for diagnosing periprosthetic hip infection and rarely do these discrepancies affect management.
对冷冻组织样本的组织病理学分析有助于辅助髋关节假体周围感染的术中诊断，但存在对可靠性的担忧。本研究的目的是确定冷冻和石蜡切片诊断感染的一致性率，并评估差异如何影响患者的结局。共从 62 名患者中收集了 282 个样本进行冷冻和石蜡切片分析。274 个样本（97%）的诊断结果一致。在 1 例中，差异导致持续感染时保留了假体，患者需要进一步翻修和抗生素治疗，直到感染得到控制。否则，差异不影响患者的结局。冷冻和石蜡切片在诊断髋关节假体周围感染方面具有良好的一致性，且差异很少影响处理方式。
