Division of Metabolism, Faculty of Basic Medical Sciences, Chongqing Medical University, 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, China.
J Ethnopharmacol. 2012 Jun 26;142(1):221-7. doi: 10.1016/j.jep.2012.04.048. Epub 2012 May 3.
Salacia oblonga root (SOR) is an Ayurvedic medicine for obesity and diabetes, those are associated with glucose and lipid metabolism.
SOR has been demonstrated previously to improve glucose and lipid metabolism in animal models of obesity and diabetes and to be a peroxisome proliferator-activated receptor-alpha activator. However, the anti-obesogenic and anti-diabetic mechanisms of SOR are still not largely understood. Here, we investigated the effects of SOR on lipid metabolism using laying hen, a unique animal model with a very high rate of triglyceride synthesis in the liver.
Laying hens and preadolescent pullets were treated with the layer ration containing 0%, 0.5%, or 1% SOR water extract for 4 weeks. Biochemical variables were determined enzymatically.
Laying hens showed much higher fasted triglyceride concentrations (increased by 5-13 folds) in plasma, liver, skeletal muscle and heart than pullets. 1% SOR extract treatment inhibited body weight increase without affecting food intake. Importantly, this treatment substantially attenuated hypertriglyceridemia and inhibited increases in triglyceride contents in the non-adipose tissues. However, SOR extract did not induce change in plasma glucose concentration. Moreover, SOR extract did not alter all variables in pullets.
These results demonstrate that SOR ameliorates hypertriglyceridemia and excessive ectopic fat accumulation in laying hens. These findings suggest that the triglyceride-lowering property is one of the primary effects of SOR, possibly via hepatic mechanisms.
匙羹藤根（SOR）是一种用于肥胖和糖尿病的阿育吠陀药物，这些病症与葡萄糖和脂质代谢有关。
SOR 先前已被证明可改善肥胖和糖尿病动物模型的葡萄糖和脂质代谢，并且是过氧化物酶体增殖物激活受体-α激活剂。然而，SOR 的抗肥胖和抗糖尿病机制尚未得到广泛理解。在这里，我们使用产蛋母鸡（一种肝脏中甘油三酯合成率非常高的独特动物模型）研究了 SOR 对脂质代谢的影响。
产蛋母鸡和青春期前的小鸡用含有 0％，0.5％或 1％SOR 水提取物的产蛋鸡饲料处理 4 周。用酶法测定生化变量。
产蛋母鸡的血浆、肝脏、骨骼肌和心脏中的空腹甘油三酯浓度（增加 5-13 倍）明显高于小鸡。1％SOR 提取物处理抑制体重增加，而不影响食物摄入。重要的是，这种处理可显著减轻高甘油三酯血症，并抑制非脂肪组织中甘油三酯含量的增加。然而，SOR 提取物不会引起血浆葡萄糖浓度的变化。此外，SOR 提取物不会改变小鸡的所有变量。
这些结果表明 SOR 可改善产蛋母鸡的高甘油三酯血症和过多异位脂肪积累。这些发现表明，降低甘油三酯是 SOR 的主要作用之一，可能通过肝脏机制。
