2型糖尿病患者血清视黄醇结合蛋白4与骨代谢

[Serum retinol binding protein 4 and bone metabolism in patients with type 2 diabetes].

作者信息

Ye Ailing, Zhang Hong, Peng Yiqun, Liao Eryuan

机构信息

Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha, China.

出版信息

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2012 Feb;37(2):197-202. doi: 10.3969/j.issn.1672-7347.2012.02.015.

DOI:10.3969/j.issn.1672-7347.2012.02.015

PMID:22561439

Abstract

OBJECTIVE

To determine the relation between serum concentration of retinol binding protein (RBP) 4 and markers of bone metabolism, bone mineral density (BMD) in patients with type 2 diabetes mellitus (T2DM).

METHODS

A total of 82 patients newly diagnosed with T2DM and 46 subjects with normal glucose tolerance (NGT) enrolled in the cross-sectional study. Subset analyses were performed, dividing subjects on the basis of gender into M-T2DM, F-T2DM, M-NGT, and F-NGT. The serum concentrions of RBP4, osteocalcin (OC) and C-terminal telopeptide of collagen type I (CTX) were measured with ELISA. The BMD was measured by dual-energy X-ray absorptiometry (DXA) with a Hologic QDR4500A device.

RESULTS

In both the T2DM groups, lnRBP4 showed a positive relationship with lnCTX (M-T2DM, r=0.564, P<0.01; F-T2DM, r=0.386, P=0.018), but no association with lnOC. After adjusting for age, smoking, creatinine clearance rate (CCr), and waist-to-hip ratio (WHR), lnRBP4 still showed a strong association with lnCTX in the M-T2DM group (r'=0.536, P<0.01), but not in F-T2DM (r'=0.317, P=0.072). In the NGT group, there was no relation between lnRBP4 and lnCTX or lnOC. LnRBP4 showed no association with BMD in all groups.

CONCLUSION

The level of serum RBP4 may be correlated with the bone metabolism in patients with T2DM.

摘要

目的

确定2型糖尿病（T2DM）患者血清视黄醇结合蛋白（RBP）4浓度与骨代谢标志物、骨密度（BMD）之间的关系。

方法

共有82例新诊断的T2DM患者和46例糖耐量正常（NGT）受试者纳入这项横断面研究。进行亚组分析，根据性别将受试者分为男性T2DM组（M-T2DM）、女性T2DM组（F-T2DM）、男性NGT组（M-NGT）和女性NGT组（F-NGT）。采用酶联免疫吸附测定法（ELISA）检测血清RBP4、骨钙素（OC）和Ⅰ型胶原C端肽（CTX）的浓度。使用Hologic QDR4500A设备通过双能X线吸收法（DXA）测量骨密度。

结果

在两个T2DM组中，lnRBP4与lnCTX均呈正相关（M-T2DM组，r=0.564，P<0.01；F-T2DM组，r=0.386，P=0.018），但与lnOC无相关性。在调整年龄、吸烟、肌酐清除率（CCr）和腰臀比（WHR）后，lnRBP4在M-T2DM组中仍与lnCTX呈强相关（r'=0.536，P<0.01），而在F-T2DM组中无相关性（r'=0.317，P=0.072）。在NGT组中，lnRBP4与lnCTX或lnOC均无相关性。lnRBP4在所有组中均与骨密度无相关性。