Meyer M, Paushter D, Steinmuller D R
Oregon Health Sciences University, Portland.
Transplantation. 1990 Dec;50(6):974-8. doi: 10.1097/00007890-199012000-00015.
This study evaluated the utility of duplex Doppler sonograms (DS) and the resistive index (RI) in the identification and differential diagnosis of various causes of renal allograft dysfunction. The efficacy of DS and RI was studied either during acute episodes of allograft dysfunction or during periodic posttransplantation longitudinal analyses. The unique features of each renal allograft results in poor correlative value for single isolated measurements of RI. We observed that the highest RIs were in ATN and that an RI of 0.9 was not specific for acute vascular rejection. Also, an RI of 0.9 was rare in acute cellular rejection. RI could not distinguish acute rejection, chronic rejection, CsA toxicity, or obstruction, although the mean RI was significantly different from normal in these groups. Serial studies of RI did document a change at the time of a clinical event compared to baseline. It is concluded that RI is not specific to any one clinical entity.
本研究评估了双功多普勒超声图（DS）和阻力指数（RI）在同种异体肾移植功能障碍各种病因的识别和鉴别诊断中的效用。在同种异体肾移植功能障碍的急性发作期间或移植后定期纵向分析期间，研究了DS和RI的有效性。每个同种异体肾移植的独特特征导致RI单次单独测量的相关性较差。我们观察到，最高的RI见于急性肾小管坏死（ATN），且RI为0.9并非急性血管排斥反应的特异性表现。此外，RI为0.9在急性细胞排斥反应中很少见。RI无法区分急性排斥反应、慢性排斥反应、环孢素A（CsA）毒性或梗阻，尽管这些组的平均RI与正常相比有显著差异。与基线相比，RI的系列研究确实记录了临床事件发生时的变化。得出的结论是，RI并非任何一种临床实体所特有。
