Islam M Z, Islam Q R, Roy S, Akhter N, Hoque M M
Department of Paediatrics, Sir Salimullah Medical College, Mitford Hospital, Dhaka, Bangladesh.
Mymensingh Med J. 2012 Apr;21(2):286-91.
Although human milk is generally accepted as the gold standard for the feeding of term infants, its use in the preterm and very low birth weight (VLBW) infants particularly in the initial period of birth has been more controversial. Little is known about the risks and benefits of early introduction of breast feeding on preterm VLBW infants. The primary object of this study was to evaluate the safety and benefit of early breast milk feeding in preterm VLBW newborns during their initial hospitalization periods. Therefore a prospective observational study was conducted among 37 preterm VLBW infants who were admitted to the Neonatal ward of Sir Salimullah Medical College and Mitford Hospital during the period of February 15th to July 25th, 2003. Oral feeding with breast milk was started within one hour of birth, and weight gain, feeding tolerance, nosocomial infection rate as well as other associated problems of pre-maturity, and postnatal growth curve were recorded upto 16th postnatal day. Seventy three percent of the newborns tolerate breast milk well from the very beginning, and the rest did not tolerate initially but all of them tolerate within 24 hours of birth. Infants had less initial weight loss (20 ± 10 gm) and faster recovery of birth weight. They regained their birth weight at 12th postnatal day. Hyper-bilirubinaemia was found in only 22% cases, and was observed in the group who initially didn't tolerate breast milk and was on intravenous fluid. Nobody developed symptomatic hypoglycemia or necrotizing enterocolitis (NEC). Two cases of sepsis and another two cases of minor infection like conjunctivitis and oral thrush have occurred. In conclusion it can be said that early breast milk feeding is safe in preterm VLBW infants and it helps to promote growth and reduce the need for intravenous line.
尽管人乳通常被认为是足月儿喂养的金标准,但在早产儿和极低出生体重(VLBW)儿中使用,尤其是在出生后的最初阶段,一直存在更多争议。关于早产VLBW儿早期进行母乳喂养的风险和益处知之甚少。本研究的主要目的是评估早产VLBW新生儿在最初住院期间早期母乳喂养的安全性和益处。因此,在2003年2月15日至7月25日期间,对37名入住萨利姆ullah爵士医学院和米特福德医院新生儿病房的早产VLBW儿进行了一项前瞻性观察研究。出生后1小时内开始用母乳进行经口喂养,并记录出生后16天内的体重增加、喂养耐受性、医院感染率以及其他与早产相关的问题和出生后生长曲线。73%的新生儿从一开始就对母乳耐受良好,其余新生儿最初不耐受,但在出生后24小时内均耐受。婴儿出生后最初体重减轻较少(20±10克),出生体重恢复较快。他们在出生后第12天恢复到出生体重。仅22%的病例出现高胆红素血症,且见于最初不耐受母乳且接受静脉输液的组。无人发生有症状的低血糖或坏死性小肠结肠炎(NEC)。发生了2例败血症以及另外2例如结膜炎和口腔鹅口疮等轻微感染病例。总之,可以说早产VLBW儿早期母乳喂养是安全的,有助于促进生长并减少静脉输液需求。