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线粒体来拯救了。

Mitochondria to the rescue.

机构信息

Texas A&M Health Science Center College of Medicine Institute for Regenerative Medicine at Scott & White, Temple, USA.

出版信息

Nat Med. 2012 May 4;18(5):653-4. doi: 10.1038/nm.2769.

DOI:10.1038/nm.2769
PMID:22561816
Abstract

A new study using a mouse model of lung diseases is the first demonstration in vivo that bone marrow–derived stromal cells can repair tissue injury through the transfer of mitochondria (pages 759-765). This suggests that rescue of injured cells through mitochondrial transfer may be an important process in many diseases.

摘要

一项使用肺部疾病小鼠模型的新研究首次在体内证明了骨髓基质细胞可以通过转移线粒体来修复组织损伤(第 759-765 页)。这表明,通过线粒体转移来拯救受损细胞可能是许多疾病中的一个重要过程。

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本文引用的文献

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Mitochondrial transfer from bone-marrow-derived stromal cells to pulmonary alveoli protects against acute lung injury.骨髓基质细胞向肺泡转移线粒体可防止急性肺损伤。
Nat Med. 2012 Apr 15;18(5):759-65. doi: 10.1038/nm.2736.
2
Mesenchymal stem cells transfer mitochondria to the cells with virtually no mitochondrial function but not with pathogenic mtDNA mutations.间充质干细胞将线粒体转移到几乎没有线粒体功能的细胞中,但不会转移有病原体的 mtDNA 突变的线粒体。
PLoS One. 2012;7(3):e32778. doi: 10.1371/journal.pone.0032778. Epub 2012 Mar 6.
3
Medical therapies with adult stem/progenitor cells (MSCs): a backward journey from dramatic results in vivo to the cellular and molecular explanations.
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ACS Appl Bio Mater. 2022 Jul 18;5(7):3281-3289. doi: 10.1021/acsabm.2c00263. Epub 2022 Jun 23.
4
BMI1 Silencing Induces Mitochondrial Dysfunction in Lung Epithelial Cells Exposed to Hyperoxia.BMI1基因沉默在暴露于高氧环境的肺上皮细胞中诱导线粒体功能障碍。
Front Physiol. 2022 Mar 30;13:814510. doi: 10.3389/fphys.2022.814510. eCollection 2022.
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Ways and Means of Cellular Reconditioning for Kidney Regeneration.肾脏再生的细胞修复方法与手段。
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