Edwards G, Weston A H
Department of Physiological Sciences, University of Manchester, UK.
Trends Pharmacol Sci. 1990 Oct;11(10):417-22. doi: 10.1016/0165-6147(90)90149-3.
Seven groups of synthetic agent, distinguished by a combination of their chemical and pharmacological characteristics exert some or all of their effects by opening plasmalemmal K+ channels primarily in smooth muscle. Progress over the past two years now allows broad structure-activity relationships to be formulated within many of the individual groups of agent. Gillian Edwards and Arthur Weston review the historical basis of these discoveries and comment on the significance of new developments. They focus on the search for tissue and channel selectivity, two factors likely to be important for the successful clinical deployment of these substances as antihypertensive and bronchodilator agents.
七组合成剂，根据其化学和药理学特性的组合加以区分，主要通过打开平滑肌中的质膜钾通道发挥部分或全部作用。过去两年的研究进展使得现在能够在许多单个剂组内制定广泛的构效关系。吉莉安·爱德华兹和亚瑟·韦斯顿回顾了这些发现的历史基础，并对新进展的意义进行了评论。他们专注于寻找组织和通道选择性，这两个因素对于将这些物质成功临床用作抗高血压和支气管扩张剂可能很重要。
