Department of Obstetrics and Gynecology, Shimane University School of Medicine, 89-1 Enyacho, Izumo, Shimane, 6938501, Japan.
Arch Gynecol Obstet. 2012 Sep;286(3):711-5. doi: 10.1007/s00404-012-2356-9. Epub 2012 May 5.
Umbilical metastasis (Sister Mary Joseph's nodule) is a rare physical sign seen only in 1-3 % of patients with an intra-abdominal and/or pelvic malignancy. Here, we present a case of Sister Mary Joseph's (SMJN) nodule originating from a primary squamous cell carcinoma of the endometrium, a rare histological subtype.
SMJN was detected in a 30-year-old woman after a preoperative CT scan for a suspected umbilical hernia. Subsequent laparotomy and histopathological examination confirmed endometrial squamous cell carcinoma metastasizing to the umbilical region.
The SMJN may be the first presenting sign of an intra-abdominal and/or pelvic malignancy and may co-exist with an umbilical hernia. Therefore, malignancy should be considered one of the differentials of an umbilical mass.
脐转移（Sister Mary Joseph 结节）是一种罕见的体表征象，仅见于 1-3%的腹腔内和/或盆腔恶性肿瘤患者。在此，我们报告一例源自子宫内膜原发性鳞状细胞癌的 Sister Mary Joseph（SMJN）结节，这是一种罕见的组织学亚型。
SMJN 在一名 30 岁女性因疑似脐疝行术前 CT 扫描时被发现。随后的剖腹手术和组织病理学检查证实了子宫内膜鳞状细胞癌转移至脐部。
SMJN 可能是腹腔内和/或盆腔恶性肿瘤的首发表现，且可能与脐疝并存。因此，对于脐部肿块，应考虑恶性肿瘤为鉴别诊断之一。
