College of Optometry, University of Houston, TX 77204, USA.
Invest Ophthalmol Vis Sci. 2012 Jun 22;53(7):3858-64. doi: 10.1167/iovs.11-9145.
To investigate whether neuronal activity within the supraoculomotor area (SOA-monosynaptically connected to medial rectus motoneurons and encode vergence angle) of strabismic monkeys was correlated with the angle of horizontal misalignment and therefore helps to define the state of strabismus.
Single-cell neural activity was recorded from SOA neurons in two monkeys with exotropia as they performed eye movement tasks during monocular viewing.
Horizontal strabismus angle varied depending on eye of fixation (dissociated horizontal deviation) and the activity of SOA cells (n = 35) varied in correlation with the angle of strabismus. Both near-response (cells that showed larger firing rates for smaller angles of exotropia) and far-response (cells that showed lower firing rates for smaller angles of exotropia) cells were identified. SOA cells showed no modulation of activity with changes in conjugate eye position as tested during smooth-pursuit, thereby verifying that the responses were related to binocular misalignment. SOA cell activity was also not correlated with change in horizontal misalignment due to A-patterns of strabismus. Comparison of SOA population activity in strabismic animals and normal monkeys (described in the literature) show that both neural thresholds and neural sensitivities are altered in the strabismic animals compared with the normal animals.
SOA cell activity is important in determining the state of horizontal strabismus, possibly by altering vergence tone in extraocular muscle. The lack of correlated SOA activity with changes in misalignment due to A/V patterns suggest that circuits mediating horizontal strabismus angle and those that mediate A/V patterns are different.
研究斜视猴的上眼球运动区（SOA-与内直肌运动神经元单突触连接并编码聚散角）内的神经元活动是否与水平偏斜角相关，从而有助于确定斜视的状态。
在两只外斜视猴进行单眼视觉任务时，记录 SOA 神经元的单细胞神经活动。
水平斜视角度随注视眼的变化而变化（分离性水平偏斜），SOA 细胞的活动与斜视角度相关（n=35）。确定了近反应（对于较小的外斜视角度，细胞放电率较大的细胞）和远反应（对于较小的外斜视角度，细胞放电率较低的细胞）细胞。在平滑追踪期间测试了 SOA 细胞在共轭眼位置变化时的活动，没有发现活动的调制，从而验证了这些反应与双眼失配有关。SOA 细胞的活动也与由于斜视的 A 模式引起的水平失配的变化无关。与斜视动物和正常猴子（文献中描述）的 SOA 群体活动进行比较，发现与正常动物相比，斜视动物的神经阈值和神经敏感性都发生了改变。
SOA 细胞的活动对于确定水平斜视的状态很重要，可能通过改变眼外肌的聚散张力来实现。由于 A/V 模式引起的失配变化与 SOA 活动无相关性表明，调节水平斜视角度的回路与调节 A/V 模式的回路不同。
