The cell and molecular biology of glaucoma: mechanisms of retinal ganglion cell death.
作者信息
Nickells Robert W
机构信息
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA.
出版信息
Invest Ophthalmol Vis Sci. 2012 May 4;53(5):2476-81. doi: 10.1167/iovs.12-9483h.
Abstract
摘要
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JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death.JNK2 和 JNK3 是轴突损伤诱导的视网膜神经节细胞死亡的主要调节因子。
Neurobiol Dis. 2012 May;46(2):393-401. doi: 10.1016/j.nbd.2012.02.003. Epub 2012 Feb 14.
2
BBC3 (PUMA) regulates developmental apoptosis but not axonal injury induced death in the retina.BBC3（PUMA）调节视网膜发育性细胞凋亡，但不调节轴突损伤诱导的细胞死亡。
Mol Neurodegener. 2011 Jul 15;6:50. doi: 10.1186/1750-1326-6-50.
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Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol.Bcl-x(L) 将 Bax 从线粒体逆向转位到细胞质中。
Cell. 2011 Apr 1;145(1):104-16. doi: 10.1016/j.cell.2011.02.034.
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Similarities and differences between primary and secondary degeneration of the optic nerve and the effect of minocycline.视神经原发性和继发性变性的异同及米诺环素的作用。
Graefes Arch Clin Exp Ophthalmol. 2011 Jun;249(6):849-57. doi: 10.1007/s00417-010-1608-2. Epub 2011 Jan 13.
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Retinal ganglion cell loss in a rat ocular hypertension model is sectorial and involves early optic nerve axon loss.大鼠眼高压模型中的视网膜神经节细胞丢失呈扇区性，且涉及早期视神经轴突丢失。
Invest Ophthalmol Vis Sci. 2011 Jan 21;52(1):434-41. doi: 10.1167/iovs.10-5856. Print 2011 Jan.
6
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Immunobiology. 2010 Sep-Oct;215(9-10):685-91. doi: 10.1016/j.imbio.2010.05.010. Epub 2010 Jun 4.
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Histone H4 deacetylation plays a critical role in early gene silencing during neuronal apoptosis.组蛋白 H4 去乙酰化在神经元凋亡过程中的早期基因沉默中起着关键作用。
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A single nucleotide polymorphism in the Bax gene promoter affects transcription and influences retinal ganglion cell death.Bax 基因启动子中的单核苷酸多态性影响转录并影响视网膜神经节细胞死亡。
ASN Neuro. 2010 Mar 31;2(2):e00032. doi: 10.1042/AN20100003.
9
Excitotoxic death of retinal neurons in vivo occurs via a non-cell-autonomous mechanism.视网膜神经元在体内的兴奋性毒性死亡通过非细胞自主机制发生。
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