• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Advances in glaucoma treatment and management: gene therapy.

作者信息

Borrás Terete

机构信息

Department of Ophthalmology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA.

出版信息

Invest Ophthalmol Vis Sci. 2012 May 4;53(5):2506-10. doi: 10.1167/iovs.12-9483o.

DOI:10.1167/iovs.12-9483o
PMID:22562852
Abstract
摘要

相似文献

1
Advances in glaucoma treatment and management: gene therapy.青光眼治疗与管理的进展：基因治疗
Invest Ophthalmol Vis Sci. 2012 May 4;53(5):2506-10. doi: 10.1167/iovs.12-9483o.
2
Adenoviral reporter gene transfer to the human trabecular meshwork does not alter aqueous humor outflow. Relevance for potential gene therapy of glaucoma.腺病毒报告基因转染人小梁网不会改变房水流出。对青光眼潜在基因治疗的意义。
Gene Ther. 1999 Apr;6(4):515-24. doi: 10.1038/sj.gt.3300860.
3
Mechanisms of AAV transduction in glaucoma-associated human trabecular meshwork cells.青光眼相关人小梁网细胞中腺相关病毒转导的机制
J Gene Med. 2006 May;8(5):589-602. doi: 10.1002/jgm.886.
4
Gene therapy with brain-derived neurotrophic factor as a protection: retinal ganglion cells in a rat glaucoma model.以脑源性神经营养因子进行基因治疗作为一种保护手段：大鼠青光眼模型中的视网膜神经节细胞
Invest Ophthalmol Vis Sci. 2003 Oct;44(10):4357-65. doi: 10.1167/iovs.02-1332.
5
Prostaglandin pathway gene therapy for sustained reduction of intraocular pressure.前列腺素途径基因治疗持续降低眼内压。
Mol Ther. 2010 Mar;18(3):491-501. doi: 10.1038/mt.2009.278. Epub 2009 Dec 1.
6
Genetic modification of human trabecular meshwork with lentiviral vectors.利用慢病毒载体对人小梁网进行基因改造。
Hum Gene Ther. 2001 Nov 20;12(17):2109-19. doi: 10.1089/10430340152677449.
7
Gene delivery to the eye using adeno-associated viral vectors.使用腺相关病毒载体将基因递送至眼部。
Methods. 2002 Oct;28(2):267-75. doi: 10.1016/s1046-2023(02)00232-3.
8
Lentiviral Vector-Mediated Expression of Exoenzyme C3 Transferase Lowers Intraocular Pressure in Monkeys.慢病毒载体介导的外毒素 C3 转移酶表达降低猴子的眼内压。
Mol Ther. 2019 Jul 3;27(7):1327-1338. doi: 10.1016/j.ymthe.2019.04.021. Epub 2019 May 9.
9
Gene therapy for glaucoma.青光眼的基因治疗。
Curr Opin Ophthalmol. 2011 Mar;22(2):73-7. doi: 10.1097/ICU.0b013e32834371d2.
10
Adenoviral gene transfer of active human transforming growth factor-{beta}2 elevates intraocular pressure and reduces outflow facility in rodent eyes.腺病毒载体介导的活性人转化生长因子-β2 基因转导可升高啮齿动物眼内压并降低房水流出率。
Invest Ophthalmol Vis Sci. 2010 Apr;51(4):2067-76. doi: 10.1167/iovs.09-4567. Epub 2009 Dec 3.

引用本文的文献

1
A Mini-Review on Gene Therapy in Glaucoma and Future Directions.青光眼基因治疗的小型综述及未来方向
Int J Mol Sci. 2024 Oct 14;25(20):11019. doi: 10.3390/ijms252011019.
2
scAAV2-Mediated Expression of Thioredoxin 2 and C3 Transferase Prevents Retinal Ganglion Cell Death and Lowers Intraocular Pressure in a Mouse Model of Glaucoma.scAAV2 介导的硫氧还蛋白 2 和 C3 转移酶的表达可预防青光眼小鼠模型中的视网膜神经节细胞死亡并降低眼内压。
Int J Mol Sci. 2023 Nov 13;24(22):16253. doi: 10.3390/ijms242216253.
3
The application of lentiviral vectors for the establishment of TGFβ2-induced ocular hypertension in C57BL/6J mice.
慢病毒载体在 C57BL/6J 小鼠 TGFβ2 诱导型高眼压模型建立中的应用。
Exp Eye Res. 2022 Aug;221:109137. doi: 10.1016/j.exer.2022.109137. Epub 2022 Jun 9.
4
Commentary: Understanding irreversible blindness - The need of the hour; Reversing it - The need of the future!评论：理解不可逆失明——当下之需；逆转它——未来之需！
Indian J Ophthalmol. 2021 Oct;69(10):2636-2637. doi: 10.4103/ijo.IJO_1224_21.
5
Looking into the future: Gene and cell therapies for glaucoma.展望未来：青光眼的基因和细胞治疗。
Vet Ophthalmol. 2021 Mar;24 Suppl 1(Suppl 1):16-33. doi: 10.1111/vop.12858. Epub 2021 Jan 7.
6
Promising Approach in the Treatment of Glaucoma Using Nanotechnology and Nanomedicine-Based Systems.利用纳米技术和基于纳米医学的系统治疗青光眼的有前途的方法。
Molecules. 2019 Oct 22;24(20):3805. doi: 10.3390/molecules24203805.
7
Single stranded adeno-associated virus achieves efficient gene transfer to anterior segment in the mouse eye.单链腺相关病毒可有效将基因导入小鼠眼前节。
PLoS One. 2017 Aug 1;12(8):e0182473. doi: 10.1371/journal.pone.0182473. eCollection 2017.
8
Gene Delivery by Subconjunctival Injection of Adenovirus in Rats: A Study of Local Distribution, Transgene Duration and Safety.大鼠结膜下注射腺病毒进行基因递送：局部分布、转基因持续时间及安全性研究
PLoS One. 2015 Dec 7;10(12):e0143956. doi: 10.1371/journal.pone.0143956. eCollection 2015.
9
Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions.青光眼分子疗法的发现：挑战、成功与前景方向
J Med Chem. 2016 Feb 11;59(3):788-809. doi: 10.1021/acs.jmedchem.5b00828. Epub 2015 Sep 25.
10
Capsid Mutated Adeno-Associated Virus Delivered to the Anterior Chamber Results in Efficient Transduction of Trabecular Meshwork in Mouse and Rat.衣壳突变的腺相关病毒递送至前房可有效转导小鼠和大鼠的小梁网。
PLoS One. 2015 Jun 8;10(6):e0128759. doi: 10.1371/journal.pone.0128759. eCollection 2015.